Gómez-Uranga Angie, Guzmán-Martínez Javier, Esteve-Atiénzar Pedro Jesús, Wikman-Jorgensen Philip, Núñez-Cruz Juan Manuel, Espinosa-Del-Barrio Leticia, Hernández-Isasi Isidro, Pomares-Gómez Francisco J, Perelló-Camacho Eva, Fernández-García Nuria, Sánchez-Miralles Ángel, Giner-Galvañ Vicente
Internal Medicine Service, University Hospital San Juan de Alicante, 03550 Alicante, Spain.
Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), 46020 Valencia, Spain.
J Clin Med. 2022 Apr 26;11(9):2424. doi: 10.3390/jcm11092424.
Aim: To assess the prevalence of malnutrition, frailty, and sarcopenia and the relationships between them in patients hospitalized for COVID-19. Methods: This was a cross-sectional study of the prevalence, determinants, and associations between malnutrition (GLIM 2019 criteria), sarcopenia (SARC-F scale, dynamometry, and calf circumference), and frailty (FRAIL scale) upon discharge following hospitalization for COVID 19. Results: A total of 101 patients (67.3% men, mean age 66.3 years) were recruited. Malnutrition was diagnosed in 49.5%, sarcopenia in 32.7%, and frailty in 28.7% of patients. Of the patients with malnutrition, 48% were also sarcopenic, and 42% were frail. There was a significant association between malnutrition and the severity of pneumonia according to the CURB-65 scale (odds ratio [OR] 2.61, p = 0.036), between sarcopenia and a Barthel score lower than 60 points (OR 29.52, p < 0.001), and between frailty and both a Barthel score lower than 60 points (OR 32.27, p < 0.001) and a length of hospital stay of over 30 days (OR 9.11, p = 0.008). Conclusions: Malnutrition, sarcopenia, and frailty are prevalent and interrelated entities in patients hospitalized for acute SARS CoV-2 infection, especially in patients with greater baseline functional impairment prior to admission and a higher infection severity.
评估因新型冠状病毒肺炎（COVID-19）住院患者中营养不良、衰弱和肌肉减少症的患病率及其相互关系。方法：这是一项横断面研究，旨在探讨COVID-19住院患者出院时营养不良（2019年全球营养不良领导倡议（GLIM）标准）、肌肉减少症（SARC-F量表、握力测定和小腿围）和衰弱（FRAIL量表）的患病率、决定因素及相关性。结果：共纳入101例患者（男性占67.3%，平均年龄66.3岁）。49.5%的患者被诊断为营养不良，32.7%为肌肉减少症，28.7%为衰弱。在营养不良患者中，48%同时患有肌肉减少症，42%存在衰弱。根据CURB-65量表，营养不良与肺炎严重程度之间存在显著关联（比值比[OR]2.61，p = 0.036）；肌肉减少症与Barthel评分低于60分之间存在显著关联（OR 29.52，p < 0.001）；衰弱与Barthel评分低于60分（OR 32.27，p < 0.001）以及住院时间超过30天（OR 9.11，p = 0.008）均存在显著关联。结论：在因急性严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染住院的患者中，尤其是入院前基线功能损害较大且感染严重程度较高的患者，营养不良、肌肉减少症和衰弱是普遍存在且相互关联的情况。
