使用低剂量计算机断层扫描通过第一腰椎的肌肉表面指数测定低肌肉量
Determination of Low Muscle Mass by Muscle Surface Index of the First Lumbar Vertebra Using Low-Dose Computed Tomography.
作者信息
Wang Ping-Huai, Gow Chien-Hung, Chiu Yen-Ling, Li Tien-Chi
机构信息
Division of Pulmonology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan.
Department of Nursing, Asia Eastern University of Science and Technology, New Taipei City 220, Taiwan.
出版信息
J Clin Med. 2022 Apr 26;11(9):2429. doi: 10.3390/jcm11092429.
The muscle index of the first vertebra (L1MI) derived from computed tomography (CT) is an indicator of total skeletal muscle mass. Nevertheless, the cutoff value and utility of L1MI derived from low-dose chest CT (LDCT) remain unclear. Adults who received LDCT for health check-ups in 2017 were enrolled. The cutoff values of L1MI were established in subjects aged 20-60 years. The cutoff values were used in chronic obstructive pulmonary disease (COPD) patients to determine muscle quantity. A total of 1780 healthy subjects were enrolled. Subjects ( = 1393) aged 20-60 years were defined as the reference group. The sex-specific cutoff values of L1MI were 26.2 cm/m for males and 20.9 cm/m for females. Six subjects in the COPD group (6/44, 13.6%) had low L1MI. COPD subjects with low L1MI had lower forced expiratory volume in one second (0.81 ± 0.17 vs. 1.30 ± 0.55 L/s, = 0.046) and higher COPD assessment test scores (19.5 ± 2.6 vs. 15.0 ± 4.9, = 0.015) than those with normal L1MI. In conclusion, LDCT in health assessments may provide additional information on sarcopenia.
通过计算机断层扫描（CT）得出的第一腰椎肌肉指数（L1MI）是骨骼肌总质量的一个指标。然而，低剂量胸部CT（LDCT）得出的L1MI的临界值及效用仍不明确。纳入了2017年接受LDCT健康检查的成年人。在20至60岁的受试者中确定了L1MI的临界值。将这些临界值用于慢性阻塞性肺疾病（COPD）患者以确定肌肉量。共纳入1780名健康受试者。年龄在20至60岁的受试者（n = 1393）被定义为参照组。L1MI的性别特异性临界值男性为26.2 cm/m，女性为20.9 cm/m。COPD组中有6名受试者（6/44，13.6%）L1MI较低。L1MI较低的COPD受试者一秒用力呼气量较低（0.81±0.17 vs. 1.30±0.55 L/s，P = 0.046），且COPD评估测试得分较高（19.5±2.6 vs. 15.0±4.9，P = 0.015），高于L1MI正常的受试者。总之，健康评估中的LDCT可能会提供有关肌肉减少症的额外信息。
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