Lee Jiyun, Park Chan Kee, Jung Kyoung In
Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
J Clin Med. 2022 Apr 28;11(9):2478. doi: 10.3390/jcm11092478.
This study aims to investigate whether parapapillary choroidal microvasculature dropout (MvD) is related to visual function measured by pattern electroretinogram (PERG) in glaucomatous eyes with β-zone parapapillary atrophy (PPA). A total of 79 patients with open angle glaucoma and preperimetric glaucoma with β-zone PPA was included in this cross-sectional study. Through the deep layer of the Swept-source optical coherence tomography angiography image, the angular width and the area of MvD were measured. Visual function was evaluated with a standard automated perimetry and PERG. N95 and P50 PERG amplitudes in eyes with MvD were noticeably decreased compared to those without MvD ( = 0.004 and = 0.007, respectively), although the mean deviation was not significantly different ( = 0.107). The lower N95 amplitude was associated with the presence of MvD (β = -0.668, = 0.017) and wider angular width of MvD (B = -7.612, = 0.014). Old age ( = 0.001), average ganglion cell's inner plexiform layer thickness ( = 0.003), and the presence of MvD ( = 0.020) were significantly related to low N95 amplitude. Association between the presence and extent of the MvD and PERG amplitudes suggests that the presence of MvD has relevance to the generalized dysfunction of retinal ganglion cells.
本研究旨在调查在伴有β区视盘旁萎缩（PPA）的青光眼眼中，视盘旁脉络膜微血管缺失（MvD）是否与通过图形视网膜电图（PERG）测量的视觉功能相关。本横断面研究共纳入79例患有开角型青光眼和视野检查前期青光眼且伴有β区PPA的患者。通过扫频源光学相干断层扫描血管造影图像的深层，测量MvD的角宽度和面积。使用标准自动视野计和PERG评估视觉功能。与无MvD的眼睛相比，有MvD的眼睛中N95和P50 PERG振幅明显降低（分别为=0.004和=0.007），尽管平均偏差无显著差异（=0.107）。较低的N95振幅与MvD的存在（β=-0.668，=0.017）和MvD较宽的角宽度相关（B=-7.612，=0.014）。年龄较大（=0.001）、神经节细胞内丛状层平均厚度（=0.003）以及MvD的存在（=0.020）与低N95振幅显著相关。MvD的存在和程度与PERG振幅之间的关联表明，MvD的存在与视网膜神经节细胞的广泛功能障碍有关。
