Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Sci Rep. 2019 Nov 14;9(1):16813. doi: 10.1038/s41598-019-53354-4.
In the glaucoma clinic, patients with normal intraocular pressure (IOP) can sometimes show visual field (VF) progression. Therefore, clarification of relationship between vascular status and glaucomatous VF deterioration is a focus of interest. We used optical coherence tomography angiography (OCTA), with the aim of evaluating the relationship between vessel density (VD) and VF progression in glaucoma patients. We included 104 eyes with open angle glaucoma who were followed up for at least 5 years in this retrospective case-control study. Superficial and deep VD of macula were assessed by OCTA. Regression analysis and Cox proportional hazards model were used to identify factors significantly associated with VF progression. In logistic regression analysis determining VF progression from Guided Progression Analysis (GPA) program, initial IOP and deep macular VD were significantly associated with VF progression in multivariate analysis (P = 0.019 and 0.004). Cox proportional hazards model also identified deep macular VD as significantly related to VF progression (P = 0.035). In conclusion, initial IOP and deep VD were related to VF deterioration in glaucoma. Deep VD might be used as a surrogate of glaucomatous VF progression related with vascular incompetence.
在青光眼门诊中，眼压正常的患者有时会出现视野（VF）进展。因此，阐明血管状态与青光眼 VF 恶化之间的关系是研究的重点。我们使用光相干断层扫描血管造影（OCTA），旨在评估青光眼患者血管密度（VD）与 VF 进展之间的关系。在这项回顾性病例对照研究中，我们纳入了 104 只患有开角型青光眼且至少随访 5 年的眼。通过 OCTA 评估黄斑区浅层和深层 VD。回归分析和 Cox 比例风险模型用于确定与 VF 进展显著相关的因素。在确定 GPA 程序中 VF 进展的逻辑回归分析中，初始眼压和黄斑深层 VD 在多变量分析中与 VF 进展显著相关（P=0.019 和 0.004）。Cox 比例风险模型也确定黄斑深层 VD 与 VF 进展显著相关（P=0.035）。总之，初始眼压和黄斑深层 VD 与青光眼的 VF 恶化有关。深层 VD 可能可作为与血管功能不全相关的青光眼 VF 进展的替代指标。
