Nakagawa Yoshihito, Akao Yukihiro, Yamashita Hiromi, Tahara Tomomitsu, Funasaka Kohei, Nagasaka Mitsuo, Kuzuya Teiji, Miyahara Ryoji, Hashimoto Senju, Shibata Tomoyuki, Hirooka Yoshiki
Department of Gastroenterology and Hepatology, School of Medicine, Fujita Health University, Kutsukake-cho, Toyoake 470-1192, Aichi, Japan.
The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu 501-1193, Gifu, Japan.
J Clin Med. 2022 May 6;11(9):2604. doi: 10.3390/jcm11092604.
Small intestinal tumors (adenoma and adenocarcinoma, SIT) are rare, and their microRNA (miRNA) expression profiles have not been established. Previously, we reported a relationship between miRNA expression profiles and the development, growth, morphology, and anticancer drug resistance of colorectal tumors. Here, we demonstrate that the miRNA expression profile of SIT is significantly different from those of tumors of the colon. We compared the onco-related miRNA expression profiles of SIT and colorectal tumors and found them to be different from each other. The expressions of miR-143 and miR-145 were frequently downregulated in SIT and colorectal tumors but not in sessile serrated adenoma/polyp tumors. The profiles of SIT and colorectal carcinomas of miR-7, miR-21, and miR-34a were considerably different. Upregulation of miR-31 expression was not found in any SIT cases. Our data suggested that miR-143 and miR-145 might act as anti-oncomirs common to adenocarcinoma of the small intestine, similar to those of colorectal adenoma and other cancers. However, the expression profiles of the other miRNAs of SIT were significantly different from those of colorectal tumors. These findings contribute useful insights into the tumor development and diagnosis of SIT.
小肠肿瘤（腺瘤和腺癌，SIT）较为罕见，其微小RNA（miRNA）表达谱尚未确立。此前，我们报道了miRNA表达谱与结直肠肿瘤的发生、生长、形态及抗癌药物耐药性之间的关系。在此，我们证明SIT的miRNA表达谱与结肠肿瘤的miRNA表达谱显著不同。我们比较了SIT与结直肠肿瘤的肿瘤相关miRNA表达谱，发现它们彼此不同。miR-143和miR-145的表达在SIT和结直肠肿瘤中经常下调，但在无蒂锯齿状腺瘤/息肉肿瘤中未下调。miR-7、miR-21和miR-34a在SIT和结直肠癌中的表达谱有很大差异。在任何SIT病例中均未发现miR-31表达上调。我们的数据表明，miR-143和miR-145可能作为小肠腺癌共有的抑癌miRNA发挥作用，类似于结直肠腺瘤和其他癌症中的情况。然而，SIT的其他miRNA的表达谱与结直肠肿瘤的表达谱显著不同。这些发现为SIT的肿瘤发生发展及诊断提供了有益的见解。
