Mizoue Yoko, Onodera Ema, Haraguchi Kazutoshi, Yusa Shin-Ichi
Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji 671-2280, Hyogo, Japan.
Department of Applied Molecular Chemistry, College of Industrial Technology, Nihon University, 1-2-1 Izumicho, Narashino 275-8575, Chiba, Japan.
Polymers (Basel). 2022 Apr 20;14(9):1678. doi: 10.3390/polym14091678.
Poly(2-methoxyethyl acrylate) (PMEA) and poly(ethylene oxide) (PEO) have protein-antifouling properties and blood compatibility. ABA triblock copolymers (PMEA-PEO-PMEA (MEOM; is average value of and )) were prepared using single-electron transfer-living radical polymerization (SET-LRP) using a bifunctional PEO macroinitiator. Two types of MEOM composed of PMEA blocks with degrees of polymerization (DP = ) of 85 and 777 were prepared using the same PEO macroinitiator. MEOM formed flower micelles with a hydrophobic PMEA (A) core and hydrophilic PEO (B) loop shells in diluted water with a similar appearance to petals. The hydrodynamic radii of MEOM and MEOM were 151 and 108 nm, respectively. The PMEA block with a large DP formed a tightly packed core. The aggregation number () of the PMEA block in a single flower micelle for MEOM and MEOM was 156 and 164, respectively, which were estimated using a light scattering technique. The critical micelle concentrations (CMCs) for MEOM and MEOM were 0.01 and 0.002 g/L, respectively, as determined by the light scattering intensity and fluorescence probe techniques. The size, , and CMC for MEOM and MEOM were almost the same independent of hydrophobic DP of the PMEA block.
聚（丙烯酸2-甲氧基乙酯）（PMEA）和聚环氧乙烷（PEO）具有抗蛋白质污染特性和血液相容性。使用双功能PEO大分子引发剂，通过单电子转移活性自由基聚合（SET-LRP）制备了ABA三嵌段共聚物（PMEA-PEO-PMEA（MEOM； 为 和 的平均值））。使用相同的PEO大分子引发剂制备了两种由聚合度（DP = ）分别为85和777的PMEA嵌段组成的MEOM。MEOM在稀释水中形成了具有疏水PMEA（A）核和亲水PEO（B）环壳的花状胶束，其外观类似于花瓣。MEOM和MEOM的流体力学半径分别为151和108 nm。具有大DP的PMEA嵌段形成了紧密堆积的核。使用光散射技术估计，单花状胶束中MEOM和MEOM的PMEA嵌段的聚集数（）分别为156和164。通过光散射强度和荧光探针技术测定，MEOM和MEOM的临界胶束浓度（CMC）分别为0.01和0.002 g/L。MEOM和MEOM的尺寸、 以及CMC几乎相同，与PMEA嵌段的疏水DP无关。
