Chernonosova Vera S, Laktionov Pavel P
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, 630055 Novosibirsk, Russia.
Polymers (Basel). 2022 Apr 21;14(9):1698. doi: 10.3390/polym14091698.
Electrospinning is a popular method used to fabricate small-diameter vascular grafts. However, the importance of structural characteristics of the scaffold determining interaction with endothelial cells and their precursors and blood cells is still not exhaustively clear. This review discusses current research on the significance and impact of scaffold architecture (fiber characteristics, porosity, and surface roughness of material) on interactions between cells and blood with the material. In addition, data about the effects of scaffold topography on cellular behaviour (adhesion, proliferation, and migration) are necessary to improve the rational design of electrospun vascular grafts with a long-term perspective.
静电纺丝是一种用于制造小直径血管移植物的常用方法。然而，支架的结构特征对其与内皮细胞及其前体细胞和血细胞相互作用的重要性仍未完全明确。本综述讨论了目前关于支架结构（材料的纤维特征、孔隙率和表面粗糙度）对细胞与血液和材料之间相互作用的意义和影响的研究。此外，关于支架拓扑结构对细胞行为（粘附、增殖和迁移）影响的数据对于从长远角度改进静电纺丝血管移植物的合理设计是必要的。
