The Department of Biomedical Engineering, The University of South Dakota, Sioux Falls, SD 57107, United States of America.
The Department of Biomedical Engineering, The University of South Dakota, Sioux Falls, SD 57107, United States of America.
Mater Sci Eng C Mater Biol Appl. 2021 Oct;129:112373. doi: 10.1016/j.msec.2021.112373. Epub 2021 Aug 14.
Due to the prevalence of cardiovascular diseases, there is a large need for small diameter vascular grafts that cannot be fulfilled using autologous vessels. Although medium to large diameter synthetic vessels are in use, no suitable small diameter vascular graft has been developed due to the unique dynamic environment that exists in small vessels. To achieve long term patency, a successful tissue engineered vascular graft would need to closely match the mechanical properties of native tissue, be non-thrombotic and non-immunogenic, and elicit the proper healing response and undergo remodeling to incorporate into the native vasculature. Electrospinning presents a promising approach to the development of a suitable tissue engineered vascular graft. This review provides a comprehensive overview of the different polymers, techniques, and functionalization approaches that have been used to develop an electrospun tissue engineered vascular graft.
由于心血管疾病的流行，对小直径血管移植物的需求很大，而这些移植物不能用自体血管来满足。虽然中到大直径的合成血管在使用中，但由于小血管中存在独特的动态环境，还没有开发出合适的小直径血管移植物。为了实现长期通畅，一个成功的组织工程血管移植物需要与天然组织的机械性能非常匹配，具有抗血栓和免疫原性，并且能够引发适当的愈合反应并进行重塑以融入到天然血管中。静电纺丝为开发合适的组织工程血管移植物提供了一种很有前途的方法。本综述全面概述了为开发静电纺组织工程血管移植物而使用的不同聚合物、技术和功能化方法。
