Zhang Hongguang, Liu Lijia, Hou Peng, Pan Hong, Fu Shuang
College of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
Key Laboratory of Superlight Materials & Surface Technology, Ministry of Education, Institute of Advanced Marine Materials, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, China.
Polymers (Basel). 2022 Apr 24;14(9):1737. doi: 10.3390/polym14091737.
The development of non-polluting and non-hazardous polymeric antimicrobial agents has become a hot issue in current research and development. Among them, polymer quaternary ammonium salts are thought to be one of the most promising materials for antibacterial efficacy. Here, we present an efficient strategy for synthesizing polyisocyanide quaternary ammonium salts (PQASs) with a novel star-shaped structure. Benefitting from the novel structure, increased cation density and enhanced water solubility, the prepared star polyisocyanide quaternary ammonium salts (S-PQASs) exhibit excellent antibacterial properties against () and (). In particular, S-POcQAS-M (where M stands for isonitrile monomer and 50 stands for the initial feeding ratio) showed the best antimicrobial activity with minimum inhibitory concentration (MIC) of 17 and 20 µg/mL against and , respectively. It was also found that the unique star-shaped structure can give QASs with improved antimicrobial performance compared with our previously prepared linear quaternary ammonium salts (L-PQASs). These results demonstrated that the antibacterial activity of QASs is closely related to its structure. This work provides an idea for the design of efficient polymeric antimicrobial agents.
开发无污染、无危害的聚合物抗菌剂已成为当前研发中的热点问题。其中，聚合物季铵盐被认为是具有抗菌功效的最具前景的材料之一。在此，我们提出一种高效策略，用于合成具有新型星形结构的聚异腈季铵盐（PQASs）。得益于这种新型结构、增加的阳离子密度和增强的水溶性，所制备的星形聚异腈季铵盐（S-PQASs）对（）和（）表现出优异的抗菌性能。特别地，S-POcQAS-M（其中M代表异腈单体，50代表初始进料比）表现出最佳的抗菌活性，对（）和（）的最低抑菌浓度（MIC）分别为17和20 µg/mL。还发现，与我们之前制备的线性季铵盐（L-PQASs）相比，独特的星形结构可使季铵盐具有更好的抗菌性能。这些结果表明，季铵盐的抗菌活性与其结构密切相关。这项工作为高效聚合物抗菌剂的设计提供了思路。
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