Shih Yu-Tung, Chen An-Pang, Lai Mei-Feng, Lin Mei-Chen, Shiu Bing-Chiuan, Lou Ching-Wen, Lin Jia-Horng
Division of General Neurosurgery, Jen-Ai Hospital, Dali District, Taichung City 412224, Taiwan.
Technical Center, Fujian Changyuan Textile Co., Ltd., Fuzhou 350200, China.
Polymers (Basel). 2022 Apr 26;14(9):1764. doi: 10.3390/polym14091764.
To reduce the bleeding time and to shorten the surgery time are vital to patients' prog-nosis, therefore, in this study, high moisture absorption nonwoven composites are proposed to attain hemostasis in time. Polyacrylate fiber and Tencel fibers at different blending ratios (10:90, 20:80, 30:70, 40:60, and 50:50) are used to form PT composite nonwoven. Next, composed of a 50:50 ratio, PT composite nonwoven exhibits the maximal vertical wicking height of 4.4 cm along the cross direction. Additionally, the UV-Vis absorption spectra analysis shows that at absorption waves of 413-415 nm, the occurring of distinct peaks suggests the presence of nanoparticles. The XRD patterns indicate the presence of silver nanoparticles with corresponding crystal planes of characteristic peaks at (111), (200), and (220). Polyacrylate/Tencel nonwoven composites exhibit comparable adsorption capacity of blood and water molecules. In particular, 30PT composite nonwoven outperforms the control group, exhibiting 3.8 times and 4.7 times greater the water absorption and blood absorption, respectively. Moreover, a great number of red blood cells with a size of 4-6 μm agglomerate among fibers as observed in SEM images, while 6hr-PT composite dressing demonstrates the optimal antibacterial efficacy against Escherichia coli and Staphylococcus aureus, proven by the zone of inhibition being 1.9 mm and 0.8 mm separately. When in contact with plasma, hemostasis composites have plasma hemostasis prothrombin time of 97.9%, and activated partial thromboplastin time of 96.7%. As for animal hemostasis model, the arteria over the rats' thigh bones is cut open perpendicularly, generating mass arteria hemorrhage. To attain hemostasis, it takes 46.5% shorter time when using composite dressings (experimental group) than the control group.
缩短出血时间和手术时间对患者的预后至关重要，因此，在本研究中，提出使用高吸湿非织造复合材料来及时实现止血。采用不同混合比例（10:90、20:80、30:70、40:60和50:50）的聚丙烯腈纤维和天丝纤维来制备PT复合非织造布。接下来，由50:50比例组成的PT复合非织造布在横向方向上表现出最大垂直芯吸高度为4.4 cm。此外，紫外可见吸收光谱分析表明，在413 - 415 nm的吸收波长处，出现明显的峰表明存在纳米颗粒。X射线衍射图谱表明存在银纳米颗粒，其特征峰的相应晶面为(111)、(200)和(220)。聚丙烯腈/天丝非织造复合材料表现出相当的血液和水分子吸附能力。特别是，30PT复合非织造布优于对照组，其吸水和吸血能力分别比对照组高3.8倍和4.7倍。此外，在扫描电子显微镜图像中观察到大量尺寸为4 - 6μm的红细胞聚集在纤维之间，而6小时-PT复合敷料对大肠杆菌和金黄色葡萄球菌表现出最佳抗菌效果，抑菌圈分别为1.9 mm和0.8 mm。当与血浆接触时，止血复合材料的血浆止血凝血酶原时间为97.9%，活化部分凝血活酶时间为96.7%。对于动物止血模型，垂直切开大鼠大腿骨上方的动脉，造成大量动脉出血。为实现止血，使用复合敷料（实验组）比对照组所需时间短46.5%。
