Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Touro University Medical Group, Stockton, CA, USA.
J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096221097522. doi: 10.1177/23247096221097522.
Sarcoidosis is well known for heterogeneity of its presentation and multisystem organ involvement. It commonly involves respiratory tract, skin, eyes, and lymph nodes, as well as hematologic and renal systems. While anemia and lymphopenia are the most common hematologic abnormalities seen in sarcoidosis, immune thrombocytopenic purpura (ITP) is considered rare. Renal abnormalities, although infrequent, are usually more likely to involve tubules rather than glomeruli. In this report, we present a case of sarcoidosis-associated ITP and focal segmental glomerulosclerosis (FSGS), refractory to first-line therapy, but successfully treated with Rituximab and thrombopoietin-receptor agonist.
结节病以其表现和多系统器官受累的异质性而闻名。它通常涉及呼吸道、皮肤、眼睛和淋巴结，以及血液系统和肾脏系统。虽然贫血和淋巴细胞减少症是结节病中最常见的血液学异常，但免疫性血小板减少性紫癜（ITP）被认为很少见。肾脏异常虽然不常见，但通常更可能涉及肾小管而不是肾小球。在本报告中，我们介绍了一例与结节病相关的 ITP 和局灶节段性肾小球硬化症（FSGS），一线治疗无效，但用利妥昔单抗和血小板生成素受体激动剂成功治疗。
