Department of Endocrinology, Central Hospital Affiliated to Shandong First Medical University, No. 105, Jiefang Road, Jinan City, Shandong, 250013, China.
Department of Kidney Disease Unit & Dialysis, Central Hospital Affiliated to Shandong First Medical University, No. 105, Jiefang Road, Jinan City, Shandong, 250013, China.
Appl Biochem Biotechnol. 2022 Sep;194(9):3914-3929. doi: 10.1007/s12010-022-03920-w. Epub 2022 May 14.
Diabetes is an amalgamation of metabolic disorders marked by hyperglycemia. Over time diabetes brings up several other complications with it like cardiovascular disease, retinopathy, neuropathy, and nephropathy. among which diabetic nephropathy (DN) is the one we are concerned about in the present study. Diabetes management requires following a healthy lifestyle with proper medication. Most of the anti-diabetic drugs available at present come with adverse side effects. Nature has provided us with several components that are anti-diabetic in nature which has fewer or no side effects and tangeretin is one among them. Tangeretin is a natural flavonoid abundantly present in orange peel and tangerines. Our study is designed to evaluate tangeretin, as an anti-diabetic medication especially for patients suffering from diabetic nephropathy. The procured healthy rats were first divided into four groups: the group I was maintained as healthy control and the others were subjected to the induction of diabetes by i.p. injection of streptozotocin (STZ) at the concentration of 55mg/kg b.wt .Then, the diabetic rats were further divided into three groups: group II was used as the diabetic control rats and the group III and group IV were administered with tangeretin (25mg/kg b.wt) and positive control drug metformin (150mg/kg b.wt) for 8 weeks. The body weight, blood glucose, and serum insulin levels were estimated at week 0 and week 8. Reactive oxygen species (ROS) inhibitory effect, antioxidant, antilipidemic, nephroprotective, and anti-inflammatory effects of tangeretin on the diabetic-induced rats were evaluated at the end of week 8 in addition to the histopathological assessment of the sections of the kidneys of the experimental rats. All the test results concluded that tangeretin was able to significantly decelerate the progression of DN in STZ-induced diabetic rats.
糖尿病是一种代谢紊乱的综合病症，其特征是高血糖。随着时间的推移，糖尿病会带来其他一些并发症，如心血管疾病、视网膜病变、神经病变和肾病。其中，糖尿病肾病（DN）是我们目前研究关注的问题。糖尿病的管理需要遵循健康的生活方式并适当用药。目前大多数可用的抗糖尿病药物都有不良反应。大自然为我们提供了一些具有天然抗糖尿病作用的成分，它们的副作用较小或没有，而桔皮素就是其中之一。桔皮素是一种天然类黄酮，在橙皮和橘子中含量丰富。我们的研究旨在评估桔皮素作为一种抗糖尿病药物，特别是对患有糖尿病肾病的患者。首先将采购的健康大鼠分为四组：第一组作为健康对照组，其余组通过腹腔注射链脲佐菌素（STZ）（浓度为 55mg/kg b.wt）诱导糖尿病。然后，将糖尿病大鼠进一步分为三组：第二组作为糖尿病对照组，第三组和第四组分别给予桔皮素（25mg/kg b.wt）和阳性对照药物二甲双胍（150mg/kg b.wt）治疗 8 周。在第 0 周和第 8 周测量体重、血糖和血清胰岛素水平。在第 8 周结束时，评估桔皮素对糖尿病诱导大鼠的抗氧化、抗脂、肾保护和抗炎作用，以及对实验大鼠肾脏切片的组织病理学评估。所有测试结果表明，桔皮素能够显著减缓 STZ 诱导的糖尿病大鼠中 DN 的进展。
