Medical College, Soochow University, Suzhou, 215123, Jiangsu, China.
Department of Gastroenterology, Qinghai Provincial People's Hospital, Xining, 810007, Qinghai, China.
BMC Gastroenterol. 2022 May 14;22(1):244. doi: 10.1186/s12876-022-02324-8.
Gastric cancer, or stomach cancer, that originates in the inner lining of the stomach, was the fifth most common cancer and the fourth mortality globally, with over one million new cases in 2020 and an estimated 769,000 deaths. The molecular characteristics of gastric cancer has been complicated by histological and intratumor heterogeneity. The incidence of gastric cancer shows wide geographical variation. As the largest and highest region in China, Qinghai-Tibetan Plateau is one of the important global biodiversity hotspots. Here, we collect tumour and paired normal bio-samples from 31 primary gastric cancer patients from Qinghai Provincial People's Hospital, and discuss the molecular characteristics for gastric cancer patients living in plateau. They have more single nucleotide polymorphisms (SNP) located in chromosome 7 with C → T and G → A as the most common alteration types, barely share the cancer driver genes with western patients, and have no significant differences in various Chinese nation. These characteristics offers a great opportunity to further understanding the divergent mechanism of gastric cancer, increase the efficacy for diagnosis and prognosis, finally lead the optimal targeted therapeutics.
胃癌，即起源于胃内黏膜的癌症，是全球第五大常见癌症和第四大癌症死因，2020 年全球新增病例超过 100 万例，预估死亡病例约 76.9 万例。胃癌的分子特征因组织学和肿瘤内异质性而变得复杂。胃癌的发病率存在广泛的地域差异。作为中国最大、海拔最高的地区，青藏高原是全球重要的生物多样性热点地区之一。在这里，我们从青海省人民医院的 31 名原发性胃癌患者中收集肿瘤和配对的正常生物样本，并探讨生活在高原地区的胃癌患者的分子特征。他们有更多位于染色体 7 上的单核苷酸多态性（SNP），以 C→T 和 G→A 为最常见的改变类型，与西方患者几乎没有共同的癌症驱动基因，且在不同的中国民族之间没有显著差异。这些特征为进一步了解胃癌的差异机制提供了机会，提高了诊断和预后的疗效，最终为最佳靶向治疗提供了指导。
