基础代谢率较低与绝经后妇女发生肌骨减少症的风险增加有关。

The lower basal metabolic rate is associated with increased risk of osteosarcopenia in postmenopausal women.

机构信息

Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

BMC Womens Health. 2022 May 14;22(1):171. doi: 10.1186/s12905-022-01754-6.

DOI:10.1186/s12905-022-01754-6

PMID:35568898

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9107118/

Abstract

BACKGROUND

The goal of this study is to clarify clinical, functional, and biochemical features of postmenopausal women who are at risk of developing osteosarcopenia.

METHODS

This is a cross-sectional study undertaken to investigate the co-accordance of osteoporosis and sarcopenia and common risk factors on 305 postmenopausal Iranian women. Sarcopenia and osteoporosis were defined based on the European Working Group on sarcopenia in Older People guidelines and WHO criteria, respectively. Confounding factors including age, menopausal age, obesity, sun exposure, physical activity, macronutrient composition, and calcium and vitamin D supplementations were considered for all participants. A multivariate model was used to consider the common risk factors of both disorders; osteoporosis and sarcopenia.

RESULTS

The mean age was 57.9 years ± 6.0 SD (range: 48-78 years) and 37.4% of patients were 60 years or older. Among all participants, 35.7% were obese (BMI ≥ 30 kg/m). Approximately 45% of all the study population had insufficient physical activity and at least half of participants had insufficient intake of protein. There was a significant correlation between bone density and muscle mass and basal metabolic rate (BMR) (p < 0.01). In multivariate-multivariable regression model, after Bonferroni correction for obesity, lower BMR was the only one associated with both lower muscle mass and bone density in lumbar and hip sites (p < 0.007).

CONCLUSIONS

Our data suggest that low BMR might be an early predictor for concordance of osteoporosis and sarcopenia in postmenopausal women.

摘要

背景

本研究旨在阐明处于发生骨质疏松-肌少症风险的绝经后女性的临床、功能和生化特征。

方法

这是一项横断面研究，旨在调查 305 名伊朗绝经后女性骨质疏松症和肌少症的共同一致性以及常见危险因素。肌少症和骨质疏松症分别根据欧洲老年人肌少症工作组指南和世卫组织标准定义。所有参与者均考虑了混杂因素，包括年龄、绝经年龄、肥胖、日照、体力活动、宏量营养素组成以及钙和维生素 D 补充剂。使用多变量模型考虑两种疾病（骨质疏松症和肌少症）的共同危险因素。

结果

平均年龄为 57.9 ± 6.0 岁（范围：48-78 岁），37.4%的患者年龄在 60 岁及以上。所有参与者中，35.7%为肥胖者（BMI≥30 kg/m²）。约 45%的研究人群体力活动不足，至少有一半的参与者蛋白质摄入不足。骨密度和肌肉质量与基础代谢率（BMR）之间存在显著相关性（p<0.01）。在多变量多变量回归模型中，经肥胖Bonferroni校正后，较低的 BMR 是与腰椎和髋部部位肌肉质量和骨密度均降低唯一相关的因素（p<0.007）。