Oral and Maxillofacial Department, Faculty of Dentistry, Damascus University, Damascus, Syria.
Medical Education Programme, Syrian Virtual University, Damascus, Syria.
BMC Musculoskelet Disord. 2022 May 14;23(1):454. doi: 10.1186/s12891-022-05421-7.
The temporomandibular joint (TMJ) is one of the most complex joints in the body. Temporomandibular disorders (TMD) are among the most troublesome disorders for patients, as they can cause pain, affect oral functions and disturb dentists on the level of diagnosis and treatment. The most common symptoms of temporomandibular joint disorders are articulated sounds (such as clicking or TMJ crepitation), joint pain in comfort and function situations (jaw movements), pain or strain in masseter and jaw muscles and or restricted mandibular movements. One of the most modern biocompatible substances used to treat joint disorders, including the TMJ, is platelet-rich plasma (PRP) and injectable platelet-rich fibrin (I-PRF). This study aims to evaluate the efficacy of platelet-rich fibrin (I-PRF) intra-articular injections in managing internal derangements of temporomandibular.
Twenty patients suffering from a unilateral click due to temporomandibular disorders were individually injected with 1 mL of (I-PRF) twice 1 week apart into the superior joint space of the TMJ with the internal disorder. Data were recorded and evaluated by the Helkimo index. This evaluation was conducted three times; 1 week after the first injection, 1 week after the second injection, and 6 months after the first injection.
The clicking disappeared entirely in 14 out of 20 patients after 1 week of getting the first injection, and in all patients after 1 week of getting the second injection, and returned to two of them after a six-month since the first injection.
Preliminary results showed the efficacy of the Injectable Platelet-Rich Fibrin (I-PRF) in managing articular clicking in patients with internal disorders of the temporomandibular joint. Injectable Platelet Rich Fibrin has significant clinical efficacy in treating the articular clicking resulting from internal temporomandibular joint disorders.
颞下颌关节（TMJ）是人体最复杂的关节之一。颞下颌关节紊乱（TMD）是患者最麻烦的疾病之一，因为它们会引起疼痛，影响口腔功能，并在诊断和治疗方面困扰牙医。颞下颌关节紊乱最常见的症状是关节弹响（如咔哒声或 TMJ 噼啪声）、舒适和功能状态下的关节疼痛（下颌运动）、咀嚼肌和/或下颌运动受限的疼痛或紧张。用于治疗关节疾病（包括 TMJ）的最现代的生物相容性物质之一是富血小板血浆（PRP）和可注射富血小板纤维蛋白（I-PRF）。本研究旨在评估关节内注射富血小板纤维蛋白（I-PRF）治疗颞下颌关节内紊乱的疗效。
20 名单侧因颞下颌关节紊乱而出现弹响的患者，每个关节均在 TMJ 上关节腔内注射 1ml（I-PRF），共 2 次，间隔 1 周。用 Helkimo 指数记录和评估数据。该评估共进行 3 次；第一次注射后 1 周、第二次注射后 1 周和第一次注射后 6 个月。
14 例患者在第一次注射后 1 周完全消除了弹响，所有患者在第二次注射后 1 周完全消除了弹响，6 个月后有 2 例患者恢复了弹响。
初步结果表明，可注射富血小板纤维蛋白（I-PRF）治疗颞下颌关节内紊乱患者关节弹响的疗效。可注射富血小板纤维蛋白在治疗由颞下颌关节内紊乱引起的关节弹响方面具有显著的临床疗效。
