Albilia Jonathan, Herrera-Vizcaíno Carlos, Weisleder Hillary, Choukroun Joseph, Ghanaati Shahram
Private Practitioner and Attending, Division of Oral and Maxillofacial Surgery, Department of Dentistry, Jewish General Hospital , Montreal, Canada.
Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery. FORM (Frankfurt Orofacial Regenerative Medicine) Lab, University Hospital Frankfurt Goethe University , Frankfurt am Main, Germany.
Cranio. 2020 Sep;38(5):292-304. doi: 10.1080/08869634.2018.1516183. Epub 2018 Sep 20.
To evaluate the clinical benefits of liquid platelet-rich fibrin (PRF) in patients with temporomandibular joint (TMJ) pain and dysfunction.
Forty-eight TMJs in 37 patients with painful internal derangement (ID) (Wilkes' I-V) were included. Patients were injected with 1.5-2cc of PRF within the superior joint space at 2-week intervals. Pain and subjective dysfunction were recorded using a visual analog scale. Statistical analyses were done using the ANOVA test.
Thirty-three of 48 TMJs (69%) showed significant reduction in pain at 8 weeks, and at 3, 6, and 12 months (Responders). Fifteen of 48 TMJs (31%) did not improve (Non-responders). The best Responders to liquid PRF injections were ID stages Wilkes' IV (78.5%) and V (100%), compared to Wilkes' I (0%), II (47%), and III (33%). A non-significant, but notable decrease in dysfunction was found.
Preliminary findings support that liquid PRF exhibits long-term analgesic effects in most patients with painful TMJ ID.
评估液态富血小板纤维蛋白（PRF）对颞下颌关节（TMJ）疼痛和功能障碍患者的临床疗效。
纳入37例患有疼痛性关节内紊乱（ID）（威尔克斯I - V级）患者的48个TMJ。患者每隔2周在上关节间隙注射1.5 - 2cc的PRF。使用视觉模拟量表记录疼痛和主观功能障碍情况。采用方差分析进行统计分析。
48个TMJ中的33个（69%）在8周以及3、6和12个月时疼痛显著减轻（有反应者）。48个TMJ中的15个（31%）未改善（无反应者）。与威尔克斯I级（0%）、II级（47%）和III级（33%）相比，液态PRF注射效果最佳的是威尔克斯IV级（78.5%）和V级（100%）的ID阶段。发现功能障碍虽无显著但有明显下降。
初步研究结果支持液态PRF对大多数患有疼痛性TMJ ID的患者具有长期镇痛作用。
