Department of Chemistry, University of Mumbai, Mumbai, India.
Department of Life Sciences, University of Mumbai, Mumbai, India.
J Mol Recognit. 2022 Sep;35(9):e2976. doi: 10.1002/jmr.2976. Epub 2022 Jun 4.
The synthesis of four new azo-Schiff base ligands from 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde and 4-aminoantipyrine is described in this study. The molecular structures of all the scaffolds were confirmed using NMR spectroscopies such as H and C, as well as FT-IR and Mass spectroscopy. After successful synthesis and characterization of all the ligands, their in vitro antibacterial, antioxidant and anti-inflammatory activities were carried out by using standard protocols. Results revealed that all the four ligands (L1-L4) possessed excellent biological potency.
本研究描述了由 2-羟基-3-甲氧基-5-（苯基亚氨基）苯甲醛和 4-氨基安替比林合成的四个新的偶氮席夫碱配体。所有支架的分子结构均通过 NMR 光谱（如 H 和 C）以及 FT-IR 和质谱进行了确认。在成功合成和表征所有配体后，使用标准方案进行了体外抗菌、抗氧化和抗炎活性测试。结果表明，所有四个配体（L1-L4）均具有出色的生物活性。
