高或低乳腺癌风险评估是否会降低后续乳腺癌筛查的参与率？队列研究。
Does receiving high or low breast cancer risk estimates produce a reduction in subsequent breast cancer screening attendance? Cohort study.
机构信息
Manchester Centre of Health Psychology, Division of Psychology and Mental Health, School of Health Sciences, University of Manchester, Coupland Street, Manchester, M13 9PL, England, UK; NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, England, UK.
Manchester Centre of Health Psychology, Division of Psychology and Mental Health, School of Health Sciences, University of Manchester, Coupland Street, Manchester, M13 9PL, England, UK; NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, England, UK.
出版信息
Breast. 2022 Aug;64:47-49. doi: 10.1016/j.breast.2022.05.001. Epub 2022 May 9.
Risk-stratified breast cancer screening may improve the balance of screening benefits to harms. We assess a potential new harm: reduced screening attendance in women receiving below average-risk (false reassurance) or higher-risk results (screening avoidance). Following initial screening, 26,668 women in the PROCAS study received breast cancer risk estimates, with attendance recorded for two subsequent screening rounds. First-screen attendance was slightly reduced in below-average (85.6%) but not higher-risk women, compared to other women (86.4%). Second-screen attendance increased for women at higher-risk (89.2%) but not below-average, compared to other women (78.8%). Concerns about this potential harm of risk-stratified screening therefore appear unfounded.
风险分层乳腺癌筛查可能会改善筛查的获益与危害之间的平衡。我们评估了一种潜在的新危害：接受低风险（错误保证）或高风险结果（筛查回避）的女性的筛查参与度降低。在初始筛查后，PROCAS 研究中的 26668 名女性收到了乳腺癌风险估计值，并记录了随后两次筛查的参与情况。与其他女性（86.4%）相比，低风险女性（85.6%）但并非高风险女性的首次筛查参与率略有下降。与其他女性（78.8%）相比，高风险女性（89.2%）的第二次筛查参与率有所增加。因此，对风险分层筛查可能产生这种危害的担忧似乎没有根据。
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