Department of Human and Social Sciences, University of Bergamo, Bergamo, Italy.
Department of Human and Social Sciences, University of Bergamo, Bergamo, Italy; IRCCS Mondino Foundation, Pavia, Italy.
Neuroimage Clin. 2022;35:103031. doi: 10.1016/j.nicl.2022.103031. Epub 2022 May 5.
Patients with Parkinson disease (PD) may show impairments in the social perception. Whether these deficits have been consistently reported, it remains to be clarified which brain alterations subtend them. To this aim, we conducted a neuroimaging meta-analysis to compare the brain activity during social perception in patients with PD versus healthy controls. Our results show that PD patients exhibit a significantly decreased response in the basal ganglia (putamen and pallidum) and a trend toward decreased activity in the mirror system, particularly in the left parietal cortex (inferior parietal lobule and intraparietal sulcus). This reduced activation may be tied to a disruption of cognitive resonance mechanisms and may thus constitute the basis of impaired others' representations underlying action and emotion perception. We also found increased activation in the posterior cerebellum in PD, although only in a within-group analysis and not in comparison with healthy controls. This cerebellar activation may reflect compensatory mechanisms, an aspect that deserves further investigation. We discuss the clinical implications of our findings for the development of novel social skill training programs for PD patients.
帕金森病（PD）患者可能表现出社交感知障碍。这些缺陷是否得到了一致的报道，尚不清楚哪些大脑改变与之相关。为此，我们进行了一项神经影像学荟萃分析，以比较 PD 患者与健康对照组在社交感知过程中的大脑活动。我们的研究结果表明，PD 患者在基底神经节（壳核和苍白球）的反应显著降低，在镜像系统中也有活动减少的趋势，特别是在左顶叶皮层（顶下小叶和顶内沟）。这种活性降低可能与认知共鸣机制的破坏有关，因此可能是动作和情感感知中他人表象受损的基础。我们还发现 PD 患者的后小脑活动增加，尽管只是在组内分析中，而不是与健康对照组相比。这种小脑激活可能反映了代偿机制，这是一个值得进一步研究的方面。我们讨论了我们的研究结果对开发新型 PD 患者社交技能训练计划的临床意义。
