i-Lab, Key Laboratory of Multifunctional Nanomaterials and Smart Systems, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences (CAS), 398 Ruoshui Road, Suzhou, Jiangsu, 215123, PR China.
i-Lab, Key Laboratory of Multifunctional Nanomaterials and Smart Systems, Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences (CAS), 398 Ruoshui Road, Suzhou, Jiangsu, 215123, PR China; School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, PR China.
Biosens Bioelectron. 2022 Aug 15;210:114351. doi: 10.1016/j.bios.2022.114351. Epub 2022 May 10.
Epidermal microfluidic devices with long microchannels have been developed for continuous sweat analysis, which are crucial to assess personal hydration status and underlying health conditions. However, the flow resistance in long channels and the ionic concentration variation significantly affect the accuracy of both the sweat rate and electrolyte concentration measurements. Herein, we present a novel fluidic-controlled wearable platform for synchronously dropwise-detecting the sweat rate and total electrolyte concentration. The unconventional platform consisting of a vertically shortened channel, a pair of embedded electrodes and an absorption layer, is designed to minimize the flow resistance and transform sweat fluidics into uniform micro-droplets for chronological and dropwise detection. Real-time sweat conductance is decoupled from a square-wave-like curve, where the sweat rate and electrolyte concentration can be derived from the interval time and peak value, respectively. Flexible and wearable band devices are demonstrated to show their potential application for hydration status assessment during exercises.
已经开发出具有长微通道的表皮微流控装置，用于连续汗液分析，这对于评估个人水合状态和潜在健康状况至关重要。然而，长通道中的流动阻力和离子浓度变化会显著影响汗液速率和电解质浓度测量的准确性。在这里，我们提出了一种新颖的流体控制可穿戴平台，用于同步逐滴滴检测汗液速率和总电解质浓度。该非传统平台由一个垂直缩短的通道、一对嵌入式电极和一个吸收层组成，旨在最小化流动阻力，并将汗液流体转化为均匀的微液滴，以进行顺序和逐滴滴检测。实时汗液电导率与方波样曲线解耦，其中汗液速率和电解质浓度可以分别从间隔时间和峰值中得出。柔性和可穿戴带设备的演示表明，它们在运动期间评估水合状态方面具有潜在的应用。
