MOE and Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; Center for Medical Bioinformatics, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200040, China.
Department of Respiratory Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200040, China.
Ecotoxicol Environ Saf. 2022 Jul 1;239:113610. doi: 10.1016/j.ecoenv.2022.113610. Epub 2022 May 12.
Triclosan (TCS) is a widely used synthetic antibacterial compound with ubiquitous human exposure. Animal studies have suggested the obesogenic effect of TCS exposure, but knowledge regarding its impacts on childhood obesity was limited.
To investigate the associations of TCS exposure with childhood obesity in northern China.
This study included 423 children who participated in the 7-year-old follow-up visits of Laizhou Wan Birth Cohort in Shandong, northern China. Children's TCS exposure were determined in spot urine samples via high performance liquid chromatography-tandem mass. Their height, weight, waist circumference, body fat percentage, body mass index (BMI), and waist-to-height ratio (WHtR) were measured or calculated. BMI z-score ≥ 85th percentile was defined as overweight/obesity, and WHtR ≥ 0.5 was considered to be abdominal obesity. Multivariable linear regressions, generalized linear models (GLMs), and multivariable logistic regressions were performed to examine the associations between TCS exposure and obesity measures in children.
Linear regressions showed that TCS concentrations, when treated as continuous variables, were positively associated with BMI z-score (β = 0.12, 95% CI: 0.01, 0.24) and body fat percentage (β = 0.82, 95% CI: 0.13, 1.52). When TCS concentrations were categorized as a four-level ordinal variable, the results of GLMs were similar those of continuous variables and both of the positive trends were significant (p-trend = 0.049 for BMI z-score; p-trend = 0.023 for body fat percentage). Moreover, the higher TCS levels versus reference group were associated with an approximate 2-3 fold increased risk of abdominal obesity (p-trend = 0.044).
Exposure to TCS was positively associated with obesity measures among 7-year-old children in northern, China. Given to the cross-sectional study design, a large prospective study is warranted to confirm our findings.
三氯生（TCS）是一种广泛使用的合成抗菌化合物，人类接触广泛。动物研究表明 TCS 暴露具有致肥胖作用，但关于其对儿童肥胖影响的知识有限。
调查中国北方 TCS 暴露与儿童肥胖的关系。
本研究纳入了 423 名参加中国北方莱州湾出生队列 7 岁随访的儿童。通过高效液相色谱-串联质谱法在尿液样本中检测儿童的 TCS 暴露情况。测量或计算儿童的身高、体重、腰围、体脂百分比、体重指数（BMI）和腰高比（WHtR）。BMI z 分数≥第 85 百分位数定义为超重/肥胖，WHtR≥0.5 被认为是腹型肥胖。多变量线性回归、广义线性模型（GLM）和多变量逻辑回归用于检验 TCS 暴露与儿童肥胖测量值之间的关系。
线性回归显示，TCS 浓度作为连续变量时，与 BMI z 分数呈正相关（β=0.12，95%CI：0.01，0.24）和体脂百分比（β=0.82，95%CI：0.13，1.52）。当 TCS 浓度被分类为四水平有序变量时，GLM 的结果与连续变量相似，并且两个正向趋势均具有统计学意义（p 趋势=0.049 用于 BMI z 分数；p 趋势=0.023 用于体脂百分比）。此外，与参考组相比，TCS 水平较高与腹型肥胖的风险增加约 2-3 倍相关（p 趋势=0.044）。
在中国北方，7 岁儿童 TCS 暴露与肥胖测量值呈正相关。鉴于横断面研究设计，需要进行大规模前瞻性研究来证实我们的发现。
