University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto Investigación Biosanitaria Ibs GRANADA, Granada, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 18100, Spain.
Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 18100, Spain; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Environ Res. 2019 Jun;173:443-451. doi: 10.1016/j.envres.2019.03.045. Epub 2019 Mar 22.
Childhood obesity is one of the most serious public health challenges of our times. Although an important body of experimental evidence highlights the obesogenic potential of endocrine disruptors such as bisphenol A (BPA), the epidemiological evidence remains inconclusive and limited.
To assess associations between urinary BPA concentrations and several adiposity measures in peripubertal boys from the Environment and Childhood (INMA) cohort in Granada, Spain.
BPA concentrations were determined in spot urine samples from 298 boys aged 9-11, and their weight, height, waist circumference, and percentage body fat mass were measured. Overweight/obesity was defined as BMI z-score ≥85th percentile and abdominal obesity as waist-to-height ratio (WHtR) ≥0.5. Associations were assessed using multivariable linear and logistic regression models.
In adjusted models, each natural log-unit increase in urinary BPA concentrations was associated with higher BMI z-score (β = 0.22; 95%CI = 0.03, 0.41) and increased odds of overweight/obesity (OR = 1.46; 95%CI = 1.05, 2.05). Children with higher BPA concentrations had higher WHtR values (β = 0.007; 95%CI = -0.001, 0.015), and BPA was associated with a greater risk of abdominal obesity (OR = 1.45; 95%CI = 1.03, 2.06). No associations were found with % body fat mass.
BPA may exert an obesogenic effect in peripubertal boys, potentially increasing the risk of overweight/obesity, especially abdominal obesity. However, these results should be interpreted with caution given the modest sample size and the possibilities of reverse causality and residual confounding by diet and lifestyle patterns.
儿童肥胖是我们这个时代最严重的公共卫生挑战之一。尽管大量实验证据强调了环境内分泌干扰物（如双酚 A，BPA）对肥胖的潜在作用，但流行病学证据仍不确定且有限。
评估西班牙格拉纳达环境与儿童（INMA）队列中青春期前男孩尿液中 BPA 浓度与几种肥胖指标之间的关系。
测定了 298 名 9-11 岁男孩的尿液样本中的 BPA 浓度，并测量了他们的体重、身高、腰围和体脂肪百分比。超重/肥胖定义为 BMI z 分数≥第 85 百分位数，腹部肥胖定义为腰围与身高比（WHtR）≥0.5。使用多变量线性和逻辑回归模型评估关联。
在调整后的模型中，尿液中 BPA 浓度每增加一个自然对数单位，BMI z 分数就会增加（β=0.22；95%CI=0.03，0.41），超重/肥胖的几率也会增加（OR=1.46；95%CI=1.05，2.05）。BPA 浓度较高的儿童 WHtR 值更高（β=0.007；95%CI=0.001，0.015），BPA 与腹部肥胖的风险增加相关（OR=1.45；95%CI=1.03，2.06）。但与体脂肪百分比无关联。
BPA 可能对青春期前男孩具有致肥胖作用，可能增加超重/肥胖的风险，尤其是腹部肥胖的风险。然而，鉴于样本量较小以及饮食和生活方式模式的反向因果关系和残留混杂的可能性，这些结果应谨慎解释。
