Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY 10021, USA.
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY 10021, USA; Friedman Center for Nutrition and Inflammation, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Curr Opin Immunol. 2022 Jun;76:102205. doi: 10.1016/j.coi.2022.102205. Epub 2022 May 12.
The immune system and the peripheral nervous system are distributed throughout the body and surveil vital organs utilizing various sensory mechanisms. Previous studies have demonstrated that tissue-resident innate lymphoid cells (ILCs) and neurons are heavily enriched in the body's barrier surfaces, where it is critical to detect and rapidly adapt to the changes in dietary, microbial and other environmental stimuli. However, our understanding of how these two sensory systems cooperatively integrate these diverse signals to orchestrate host responses remains incomplete. Recent research has provided insights into how neurotrophic and neuronally derived factors regulate the functions of ILCs, establishing the neuro-ILC axis as a crucial component of broader neuro-immune interactions. Further, neurons express receptors for many cytokines produced by ILCs, opening the possibility for bidirectional neuro-immune interactions in regulating tissue homeostasis and inflammation. This review highlights recent advances in the cellular and molecular mechanisms of neuro-ILC interactions and their potential therapeutic implications.
免疫系统和外周神经系统遍布全身，利用各种感觉机制监测重要器官。先前的研究表明，组织驻留固有淋巴细胞（ILC）和神经元在身体的屏障表面大量富集，在这些表面，检测和快速适应饮食、微生物和其他环境刺激的变化至关重要。然而，我们对于这两个感觉系统如何协同整合这些不同的信号来协调宿主反应的理解还不完整。最近的研究提供了关于神经营养和神经元衍生因子如何调节 ILC 功能的见解，确立了神经-ILC 轴作为更广泛神经免疫相互作用的关键组成部分。此外，神经元表达许多由 ILC 产生的细胞因子的受体，为调节组织稳态和炎症的双向神经免疫相互作用开辟了可能性。这篇综述强调了神经-ILC 相互作用的细胞和分子机制的最新进展及其潜在的治疗意义。
