Centre for Addiction and Mental Health, Toronto, Canada; Azrieli Adult Neurodevelopmental Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Centre for Addiction and Mental Health, Toronto, Canada; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Neurosci Biobehav Rev. 2022 Jul;138:104690. doi: 10.1016/j.neubiorev.2022.104690. Epub 2022 May 13.
Cross-frequency coupling (CFC), an electrophysiologically derived measure of oscillatory coupling in the brain, is believed to play a critical role in neuronal computation, learning and communication. It has received much recent attention in the study of both health and disease. We searched for literature that studied CFC during resting state and task-related activities during electroencephalography and magnetoencephalography in psychiatric disorders. Thirty-eight studies were identified, which included attention-deficit hyperactivity disorder, Alzheimer's dementia, autism spectrum disorder, bipolar disorder, depression, obsessive compulsive disorder, social anxiety disorder and schizophrenia. The systematic review was registered with PROSPERO (ID#CRD42021224188). The current review indicates measurable differences exist between CFC in disease states vs. healthy controls. There was variance in CFC at different regions of the brain within the same psychiatric disorders, perhaps this could be explained by the mechanisms and functionality of CFC. There was heterogeneity in methodologies used, which may lead to spurious CFC analyses. Going forward, standardized methodologies need to be established and utilized in further research to understand the neuropathophysiology associated with psychiatric disorders.
跨频耦合（CFC）是大脑中振荡耦合的一种电生理衍生测量指标，被认为在神经元计算、学习和通讯中发挥着关键作用。它在健康和疾病的研究中受到了广泛关注。我们搜索了在精神障碍的脑电图和脑磁图研究中，静息状态和任务相关活动期间的 CFC 相关文献。确定了 38 项研究，其中包括注意缺陷多动障碍、阿尔茨海默病痴呆、自闭症谱系障碍、双相情感障碍、抑郁症、强迫症、社交焦虑障碍和精神分裂症。系统评价在 PROSPERO（ID#CRD42021224188）中进行了注册。目前的综述表明，在疾病状态与健康对照组之间存在可测量的 CFC 差异。在同一精神障碍的不同大脑区域中，CFC 存在差异，这可能可以用 CFC 的机制和功能来解释。所使用的方法学存在异质性，这可能导致虚假的 CFC 分析。未来，需要建立和使用标准化的方法学，以便在进一步的研究中理解与精神障碍相关的神经病理生理学。
