Aliramezani Mohammad, Farrokhi Ashkan, Constantinidis Christos, Daliri Mohammad Reza
School of Cognitive Sciences (SCS), Institute for Research in Fundamental Sciences (IPM), Tehran 19568-36613, Iran.
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
STAR Protoc. 2025 Jun 23;6(3):103877. doi: 10.1016/j.xpro.2025.103877.
Phase-amplitude coupling (PAC) is a critical neural mechanism that reflects the coordination between oscillatory brain activity across different frequency bands. Here, we present a protocol for analyzing PAC in macaque monkeys. We describe steps for preprocessing local field potential (LFP), performing time-frequency decomposition, and computing PAC between distinct frequency bands. We then detail procedures for normalizing the results using surrogate data. This protocol can be applied to various experimental conditions to explore neural synchronization and its role in cognitive processes. For complete details on the use and execution of this protocol, please refer to Aliramezani et al..
相位-振幅耦合（PAC）是一种关键的神经机制，它反映了不同频段的振荡性脑活动之间的协调。在此，我们展示了一种用于分析猕猴PAC的方案。我们描述了预处理局部场电位（LFP）、进行时频分解以及计算不同频段之间PAC的步骤。然后，我们详细说明了使用替代数据对结果进行归一化的程序。该方案可应用于各种实验条件，以探索神经同步及其在认知过程中的作用。有关此方案的使用和执行的完整详细信息，请参考Aliramezani等人的研究。
