2,3-二氢苯并二恶嗪哌啶衍生物作为强效和选择性的α2c 拮抗剂。
2,3-Dihydrobenzo-dioxine piperidine derivatives as potent and selective α2c antagonists.
机构信息
Department of Medicinal Chemistry, Orion Corporation Orion Pharma, Orionintie 1, PL 65, FI-02101, Finland.
Department of Medicinal Chemistry, Orion Corporation Orion Pharma, Orionintie 1, PL 65, FI-02101, Finland.
出版信息
Bioorg Med Chem Lett. 2022 Aug 1;69:128783. doi: 10.1016/j.bmcl.2022.128783. Epub 2022 May 13.
PMID:35569686
Abstract
In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.
摘要
在本手稿中，我们通过配体设计报告了一系列苯并二氧杂环庚烷甲基哌啶衍生物，作为高效且选择性的α2C 拮抗剂，以改善先前候选分子的药代动力学。
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