Song Byeong Geun, Sinn Dong Hyun, Kang Wonseok, Gwak Geum-Youn, Paik Yong-Han, Choi Moon Seok, Lee Joon Hyeok, Koh Kwang Cheol, Paik Seung Woon
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Korean J Intern Med. 2022 Sep;37(5):1082-1087. doi: 10.3904/kjim.2021.452. Epub 2022 May 13.
Changes in the prevalence of disease over time provide valuable information from a public health perspective. We used data from Korea Military Manpower Administration medical examinations for conscription between 2003 and 2019 (n = 5,355,941), which involved young men aged 19 years, to observe changes in liver disease over time at a population level. Trends in the prevalence of hepatitis B surface antigen (HBsAg), elevated alanine aminotransferase (ALT) levels, the fibrosis-4 (FIB-4) index, obesity, and hypertension were assessed. The prevalence of HBsAg steadily decreased from 3.19% for men born in 1984 to 0.18% for men born in 2000. Among HBsAg-negative subjects, the prevalence of elevated ALT levels increased from 13.15% for men born in 1986 to 16.48% for men born in 2000. The prevalence of obesity, hypertension and the proportion with high FIB-4 scores (≥ 1.45) also increased. This population-based nationwide analysis showed a decreasing trend of HBsAg and increasing trends of possible non-alcoholic fatty liver disease.
从公共卫生角度来看，疾病患病率随时间的变化提供了有价值的信息。我们使用了韩国军事人力管理部门2003年至2019年征兵体检的数据（n = 5,355,941），这些数据涉及19岁的年轻男性，以观察人群层面肝脏疾病随时间的变化。评估了乙肝表面抗原（HBsAg）患病率、丙氨酸氨基转移酶（ALT）水平升高、纤维化-4（FIB-4）指数、肥胖和高血压的趋势。HBsAg患病率从1984年出生男性的3.19%稳步下降至2000年出生男性的0.18%。在HBsAg阴性受试者中，ALT水平升高的患病率从1986年出生男性的13.15%增至2000年出生男性的16.48%。肥胖、高血压患病率以及FIB-4评分高（≥ 1.45）的比例也有所增加。这项基于全国人群的分析显示，HBsAg呈下降趋势，而可能的非酒精性脂肪性肝病呈上升趋势。
