Tong M J, Liu S, Co R L
Gastroenterology. 1987 Apr;92(4):862-6. doi: 10.1016/0016-5085(87)90958-9.
The effect of a short course of prednisone therapy was evaluated in 8 patients with liver biopsy-verified chronic persistent hepatitis B. In 6 of the 8 (75%) patients, an abrupt fall in serum alanine aminotransferase levels after the initiation of prednisone was noted, and in 4 patients, there was an increase in serum alanine aminotransferase values after prednisone was discontinued. However, the serum levels of hepatitis B virus deoxyribonucleic acid were consistently greater than or equal to 200 pg before, during, and after the course of treatment in 7 of the 8 (87.5%) patients. All patients were initially hepatitis B e antigen-positive and remained so during the study period. These findings indicate that, unlike some patients with chronic active hepatitis B, immunosuppression with prednisone had no effect in altering hepatitis B viral replication in patients with chronic persistent hepatitis.
对8例经肝活检证实为慢性持续性乙型肝炎的患者评估了短期泼尼松治疗的效果。8例患者中有6例（75%）在开始使用泼尼松后血清丙氨酸氨基转移酶水平突然下降，4例患者在停用泼尼松后血清丙氨酸氨基转移酶值升高。然而，8例患者中有7例（87.5%）在治疗过程中及治疗前后血清乙型肝炎病毒脱氧核糖核酸水平始终大于或等于200 pg。所有患者最初乙肝e抗原均为阳性，且在研究期间一直保持阳性。这些发现表明，与一些慢性活动性乙型肝炎患者不同，泼尼松免疫抑制对慢性持续性乙型肝炎患者的乙肝病毒复制没有影响。
