Alberti A, Pontisso P, Fattovich G, Schiavon E, Chemello L, Bortolotti F, Tremolada F, Realdi G
J Infect Dis. 1986 Oct;154(4):562-9. doi: 10.1093/infdis/154.4.562.
In an assessment of the clinical relevance of serum hepatitis B virus (HBV) DNA testing in chronic HBV infection, changes in the presence of this marker were investigated by spot hybridization in 138 hepatitis B surface antigen (HBsAg)-positive patients with chronic liver disease who were followed up for one to eight years. Forty-one patients were treated with steroids, often with evidence of potentiation of viral replication, whereas 92 patients remained untreated and had no evidence of sigma agent infection during follow-up. Data analysis in these patients allowed us to determine the significance of testing for hepatitis B e antigen and for HBV DNA in the natural history of the infection. The findings indicate that sequential testing for serum HBV DNA may be of great importance in HBsAg chronic carriers with liver disease for adequate evaluation of HBV replication and for the contribution of HBV DNA to the clinical assessment of chronic hepatitis.
在一项关于慢性乙型肝炎病毒（HBV）感染中血清HBV DNA检测临床相关性的评估中，通过斑点杂交法对138例慢性肝病的乙型肝炎表面抗原（HBsAg）阳性患者进行了该标志物存在情况的变化调查，这些患者接受了1至8年的随访。41例患者接受了类固醇治疗，常有病毒复制增强的证据，而92例患者未接受治疗，随访期间无西格玛因子感染的证据。对这些患者的数据分析使我们能够确定在感染自然史中检测乙型肝炎e抗原和HBV DNA的意义。研究结果表明，对血清HBV DNA进行连续检测对于患有肝病的HBsAg慢性携带者充分评估HBV复制以及HBV DNA对慢性肝炎临床评估的贡献可能非常重要。
