Redfern J S, Lee E, Feldman M
Gastroenterology. 1987 Apr;92(4):969-77. doi: 10.1016/0016-5085(87)90972-3.
We evaluated in healthy human beings the effect of indomethacin on gastric mucosal prostaglandin concentration and on gastric mucosal damage in a placebo-controlled study. Prostaglandin E2, prostaglandin F2 alpha, and 6-keto prostaglandin F1 alpha concentrations of gastric mucosal biopsy specimens, obtained endoscopically, were measured by radioimmunoassay. Mean prostaglandin concentration of the antrum and fundus was similar. In both regions there was considerable intersubject variability in prostaglandin concentration. Repeated 50-mg oral doses of indomethacin for 4 days reduced mean prostaglandin F2 alpha and E2 concentration by 50.2% and 69.4%, respectively, in the fundus and by 40.0% and 49.7% in the antrum, but this led to no significant mucosal damage when assessed endoscopically or histologically. A single 100-mg oral dose of indomethacin reduced mean prostaglandin F2 alpha and prostaglandin E2 concentration by 81.4% and 60.9% in the fundus and by 64.2% and 57.5% in the antrum and also induced significant mucosal injury in both regions when assessed endoscopically. However, there was no correlation between degree of suppression of prostaglandin concentration by indomethacin and endoscopic evidence of mucosal damage.
在一项安慰剂对照研究中，我们评估了消炎痛对健康人体胃黏膜前列腺素浓度及胃黏膜损伤的影响。通过放射免疫分析法测定经内镜获取的胃黏膜活检标本中前列腺素E2、前列腺素F2α和6-酮前列腺素F1α的浓度。胃窦和胃底的平均前列腺素浓度相似。在这两个区域，个体间前列腺素浓度存在相当大的差异。连续4天口服50毫克消炎痛，胃底中前列腺素F2α和E2的平均浓度分别降低了50.2%和69.4%，胃窦中分别降低了40.0%和49.7%，但在内镜或组织学评估时未导致明显的黏膜损伤。单次口服100毫克消炎痛，胃底中前列腺素F2α和前列腺素E2的平均浓度分别降低了81.4%和60.9%，胃窦中分别降低了64.2%和57.5%，在内镜评估时两个区域均出现了明显的黏膜损伤。然而，消炎痛对前列腺素浓度的抑制程度与黏膜损伤的内镜表现之间没有相关性。
