Cryer B, Redfern J S, Goldschmiedt M, Lee E, Feldman M
Medical Services, Department of Veterans Affairs Medical Center, Dallas.
Gastroenterology. 1992 Apr;102(4 Pt 1):1118-23.
The effect of aging on gastric and duodenal mucosal prostaglandins has not been reported. Gastric and duodenal mucosal prostaglandin concentrations were measured in 46 healthy adults, 35 of whom were relatively young (21-40 years old) and 11 of whom were considerably more elderly (aged 52-72 years). Mucosal biopsy specimens were obtained endoscopically from the fundus, antrum, duodenal bulb, and postbulbar duodenum, and extracts were assayed for prostaglandin F2 alpha and E2 concentrations by radioimmunoassay. Older age was associated with significantly lower fundic, antral, and post-bulbar duodenal prostaglandin concentrations. A second experiment was performed in 20 additional subjects (9 younger, 11 older) to determine whether lower mucosal concentrations in older subjects were reproducible and, if so, whether reduced gastric mucosal prostaglandins would have a physiological counterpart, namely increased gastric acid secretion. As in the original experiment, fundic, antral, and postbulbar mucosal prostaglandin levels were significantly lower in older subjects than in younger subjects. Mean basal acid output was significantly higher in older than younger subjects (9.8 +/- 2.5 vs. 4.8 +/- 1.6 mmol/h). It is concluded that gastric and duodenal prostaglandin concentrations decline with aging in humans and that the decline in fundic mucosal prostaglandins is associated with an increase in gastric acid secretion.
衰老对胃和十二指肠黏膜前列腺素的影响尚未见报道。对46名健康成年人的胃和十二指肠黏膜前列腺素浓度进行了测量，其中35人相对年轻（21 - 40岁），11人年龄较大（52 - 72岁）。通过内镜从胃底、胃窦、十二指肠球部和十二指肠球后获取黏膜活检标本，并用放射免疫分析法测定提取物中前列腺素F2α和E2的浓度。年龄较大与胃底、胃窦和十二指肠球后前列腺素浓度显著降低有关。在另外20名受试者（9名较年轻，11名较年长）中进行了第二项实验，以确定老年受试者较低的黏膜浓度是否具有重复性，如果是，胃黏膜前列腺素减少是否会有生理上的对应变化，即胃酸分泌增加。与原实验一样，老年受试者的胃底、胃窦和十二指肠球后黏膜前列腺素水平显著低于年轻受试者。老年受试者的平均基础胃酸分泌量显著高于年轻受试者（9.8±2.5 vs. 4.8±1.6 mmol/h）。结论是，人类胃和十二指肠前列腺素浓度随衰老而下降，胃底黏膜前列腺素的下降与胃酸分泌增加有关。
