Faust T W, Redfern J S, Podolsky I, Lee E, Grundy S M, Feldman M
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
Gastroenterology. 1990 Mar;98(3):586-91. doi: 10.1016/0016-5085(90)90277-8.
Gastric mucosal prostaglandin E2 and F2 alpha content was evaluated in healthy human subjects who received either fish oil or olive oil (control) daily for 3 wk before exposure to aspirin or no aspirin. Two hours after aspirin administration, when mean serum salicylate concentration was approximately 12 mg/dl, gastric mucosal prostaglandin E2 and F2 alpha content was reduced by greater than 95% in the fundus and antrum (p less than 0.001) and there was endoscopic evidence of gastric mucosal damage (erosions, submucosal hemorrhages). Fish oil feeding had no significant effect on mucosal prostaglandin E2 or F2 alpha content or on the damaging effect of aspirin on the stomach, despite the fact that fish oil reduced serum triglyceride concentrations significantly. These studies indicate that the damaging effects of aspirin on the gastric mucosa are not influenced by dietary fish oil.
在健康人体受试者中评估胃黏膜前列腺素E2和F2α含量，这些受试者在接触阿司匹林或不接触阿司匹林之前，每天服用鱼油或橄榄油（对照），持续3周。服用阿司匹林两小时后，当平均血清水杨酸浓度约为12mg/dl时，胃底和胃窦的胃黏膜前列腺素E2和F2α含量降低超过95%（p<0.001），并且有胃黏膜损伤的内镜证据（糜烂、黏膜下出血）。尽管鱼油能显著降低血清甘油三酯浓度，但喂食鱼油对黏膜前列腺素E2或F2α含量或阿司匹林对胃的损伤作用没有显著影响。这些研究表明，阿司匹林对胃黏膜的损伤作用不受膳食鱼油的影响。
