在利多卡因存在的情况下，乙酰胆碱在四乙铵诱导的鸡颈二腹肌挛缩中的作用。

The role of acetylcholine in tetraethylammonium induced contractures of the chick biventer cervicis muscle in the presence of lidocaine.

作者信息

Elliott R C

出版信息

Gen Pharmacol. 1987;18(1):7-11. doi: 10.1016/0306-3623(87)90160-1.

Abstract

Lidocaine (0.92 mM) potentiated tetraethylammonium (TEA, 0.6-6 mM) induced contractures of the chick biventer cervicis muscle (BVC) in vitro. The dose ratio for TEA (EC50 in lidocaine/EC50 control) was 1.16 X 10(-3). Lidocaine (0.92 mM) blocked nerve and muscle action potentials in the BVC preparation, blocked slow fibre MEPPS, and blocked indirectly elicited muscle contraction. Lidocaine (0.92 mM) non-competitively blocked acetylcholine (ACh) induced contractures of the chick BVC. Gallamine competitively blocked ACh contractures (pA2 6.53) but produced only a relatively weak non-competitive block of TEA induced contractures in lidocaine. TEA induced contractures of the chick BVC in the presence of lidocaine probably do not involve ACh.

摘要

利多卡因（0.92毫摩尔）增强了四乙铵（TEA，0.6 - 6毫摩尔）在体外诱导的鸡双颈二腹肌（BVC）挛缩。TEA的剂量比（利多卡因中的半数有效浓度/对照中的半数有效浓度）为1.16×10⁻³。利多卡因（0.92毫摩尔）阻断了BVC标本中的神经和肌肉动作电位，阻断了慢纤维微小终板电位，并阻断了间接引发的肌肉收缩。利多卡因（0.92毫摩尔）非竞争性地阻断了乙酰胆碱（ACh）诱导的鸡BVC挛缩。加拉明竞争性地阻断了ACh挛缩（亲和力常数pA2为6.53），但对利多卡因存在时TEA诱导的挛缩仅产生相对较弱的非竞争性阻断作用。利多卡因存在时TEA诱导的鸡BVC挛缩可能不涉及ACh。