四乙铵-美索比妥在鸡颈二腹肌中诱发挛缩和微小终板电位发放。
Tetraethylammonium-methohexitone induced contractures and miniature end-plate potential discharge in the chick biventer cervicis muscle.
作者信息
Elliott R C
出版信息
Gen Pharmacol. 1986;17(6):655-9. doi: 10.1016/0306-3623(86)90296-x.
End-plate and miniature end-plate potentials (EPP, MEPP) were recorded in the chick biventer cervicis muscle in vitro. The control frequency of discharge of MEPPs was 5.97 +/- 1.04 min-1, n = 10. Methohexitone (8.8 X 10(-5) M) did not affect the frequency of MEPP discharge, but tetraethylammonium (TEA, 2.4-9.5 mM), reduced the frequency to 32.9 +/- 8.6% of the control. In the presence of neostigmine (3.3 X 10(-6) M) methohexitone (8.8 X 10(-5) M) reduced MEPP frequency to 38.7 +/- 5.4% of the control and TEA (2.4-9.5 mM) further reduced the frequency to 8.7 +/- 2.1% of the control. After a transient facilitation of the EPP, TEA (2.4-9.5 mM) in the presence of methohexitone (8.8 X 10(-5) M) and neostigmine (3.3 X 10(-6) M) markedly reduced EPP amplitude. The contractures which TEA produced in the presence of methohexitone were not due to an increase in the spontaneous release of vesicular ACh.
在体外对鸡颈二腹肌记录终板电位和微小终板电位（EPP、MEPP）。MEPP的对照发放频率为5.97±1.04次/分钟，n = 10。美索比妥（8.8×10⁻⁵ M）不影响MEPP的发放频率，但四乙铵（TEA，2.4 - 9.5 mM）将频率降低至对照的32.9±8.6%。在新斯的明（3.3×10⁻⁶ M）存在的情况下，美索比妥（8.8×10⁻⁵ M）将MEPP频率降低至对照的38.7±5.4%，而TEA（2.4 - 9.5 mM）进一步将频率降低至对照的8.7±2.1%。在短暂增强EPP之后，在美索比妥（8.8×10⁻⁵ M）和新斯的明（3.3×10⁻⁶ M）存在的情况下，TEA（2.4 - 9.5 mM）显著降低EPP幅度。TEA在美索比妥存在时产生的挛缩并非由于囊泡乙酰胆碱自发释放增加所致。
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