甲己炔巴比妥在鸡颈二腹肌骨骼肌中产生的超极化作用。

Hyperpolarization produced by methohexitone in the chick biventer cervicis skeletal muscle.

作者信息

Wali F A

出版信息

Pharmacol Res Commun. 1984 Sep;16(9):945-56. doi: 10.1016/s0031-6989(84)80031-4.

Abstract

The effect of methohexitone on endplate potential and on depolarizations produced by acetylcholine (ACh) and tetraethylammonium (TEA) was studied in the isolated chick biventer cervicis skeletal muscle using a sucrose-gap recording technique. Methohexitone (5.5-180 uM) produced concentration-dependent hyperpolarization in the chick skeletal muscle without producing an initial contracture. Methohexitone had a differential effect on the depolarizations produced by ACh (5.5 uM- 11 mM) and TEA (0.95- 48 mM); it greatly reduced the ACh whereas it increased the TEA-induced responses. It was suggested that methohexitone had a dual postjunctional action, but a presynaptic effect was not ruled out.

摘要

采用蔗糖间隙记录技术，在离体鸡颈二腹肌骨骼肌中研究了美索比妥对终板电位以及乙酰胆碱（ACh）和四乙铵（TEA）所产生的去极化的影响。美索比妥（5.5 - 180 μM）在鸡骨骼肌中产生浓度依赖性超极化，且不产生初始挛缩。美索比妥对ACh（5.5 μM - 11 mM）和TEA（0.95 - 48 mM）所产生的去极化有不同影响；它极大地降低了ACh诱导的反应，而增加了TEA诱导的反应。提示美索比妥具有双重节后作用，但不排除其有突触前效应。