Polymer Chemistry Research Group, Centre of Macromolecular Chemistry (CMaC), Department of organic and Macromolecular Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281 S4-bis, B-9000 Ghent, Belgium.
ACS Macro Lett. 2021 May 18;10(5):616-622. doi: 10.1021/acsmacrolett.1c00275. Epub 2021 Apr 30.
Sequence-encoded oligo(thioether urethane)s with two different coding monomers per backbone unit were prepared via a solid phase, two-step iterative protocol based on thiolactone chemistry. The first step of the synthetic cycle consists of the thiolactone ring opening with a primary amine, whereby the in situ released thiol is immediately reacted with an epoxide. In the second step, the thiolactone group is reinstalled to initiate the next cycle. This strategy allows to introduce two different coding monomers per synthetic cycle, rendering the resulting macromolecules especially attractive in the area of (macro)molecular data storage because of their increased data storage capacity. Subsequently, the efficiency of the herein reported synthesis route and the applicability of the dual-encoded sequence-defined macromolecules as a potential data storage platform have been demonstrated by unraveling the exact monomer order using tandem mass spectrometry techniques.
通过基于硫内酯化学的固相两步迭代法，制备了每个主链单元带有两个不同编码单体的序列编码的聚（硫醚氨酯）。合成循环的第一步由硫内酯与伯胺开环组成，由此，即时释放的巯基立即与环氧化物反应。在第二步中，重新安装硫内酯基团以引发下一个循环。该策略允许每个合成循环引入两个不同的编码单体，由于其增加的数据存储容量，使得所得大分子在（超）分子数据存储领域特别有吸引力。随后，通过串联质谱技术揭示确切的单体顺序，证明了本文报道的合成路线的效率以及双编码序列定义的大分子作为潜在数据存储平台的适用性。
