Ramade F, Baylé J D
Gen Comp Endocrinol. 1986 Oct;64(1):21-9. doi: 10.1016/0016-6480(86)90023-7.
Muscimol was injected (0.5 mg kg-1) intravenously to either intact or thalamic-lesioned animals through a chronic catheter. Plasma samples were obtained at 7-min intervals and exhibited a moderate and transient increase in corticosterone levels in both groups, together with some symptoms of light discomfort (e.g., ptiloerection or panting). All these signs disappeared within 45 to 60 min. Intraventricular injection of bicuculline (3.5 micrograms) provoked a corticosterone profile quite similar to a stress-induced polyphasic pattern. Acute stress (electrical footshocks for 30 sec) was applied 2 hr after drug treatment. In controls, the stress-induced adrenocortical response appeared to be markedly modified after muscimol injection. The usual polyphasic rebounding profile was replaced by a monophasic one. This effect of muscimol did not occur when bicuculline had been injected in the 3rd ventricle. Bicuculline alone did not alter the stress-induced profile. GABAergic treatment had no effect on the monophasic response of thalamic-lesioned birds.
通过慢性导管向完整或丘脑损伤的动物静脉注射蝇蕈醇（0.5毫克/千克）。每隔7分钟采集血浆样本，两组动物的皮质酮水平均出现中度且短暂的升高，同时伴有一些轻度不适症状（如竖毛或喘气）。所有这些症状在45至60分钟内消失。脑室内注射荷包牡丹碱（3.5微克）引发的皮质酮变化曲线与应激诱导的多相模式非常相似。药物治疗2小时后施加急性应激（30秒电休克）。在对照组中，注射蝇蕈醇后，应激诱导的肾上腺皮质反应似乎明显改变。通常的多相反弹曲线被单相曲线取代。当在第三脑室注射荷包牡丹碱时，蝇蕈醇的这种作用未发生。单独使用荷包牡丹碱不会改变应激诱导的变化曲线。GABA能治疗对丘脑损伤鸟类的单相反应没有影响。
