Ramade F, Baylé J D
Neuroendocrinology. 1984 Sep;39(3):245-50. doi: 10.1159/000123986.
Chronic vascular catheterization allowed to obtain serial blood samples before and after stress application to thalamic pigeons. Daily repetition of the same stress, at the same hour, for 5 weeks led to drastic changes in the stress-induced adrenocortical reaction. The rebounding, long-lasting rise in plasma corticosterone occurring after initial presentation of electrical footshocks was replaced by a single peak of corticosterone, lower and shorter than the initial response. Moreover, an anticipatory conditioned rise in corticosterone appeared before stress. Random distribution of stressful stimuli, thrice a day, for 5 weeks resulted in the single peak pattern of post-stress adrenocortical reaction, without any anticipatory component. When electrical footshocks were omitted after 5 weeks of daily regular presentation of stress, only the anticipatory peak in plasma corticosterone occurred. Shifting the daily lighting from the usual 06.00 a.m. to 04.00 a.m. led to a shift in the anticipatory conditioned endocrine response which appeared 2 h sooner than usual. Thalamic involvement in the process of adaptation to chronic stress is discussed.
慢性血管插管术能够在对丘脑鸽施加应激前后获取系列血样。在同一时间每天重复施加相同的应激，持续5周，导致应激诱导的肾上腺皮质反应发生剧烈变化。最初给予足部电击后出现的血浆皮质酮反弹、持续升高，被一个皮质酮单峰所取代，该单峰低于且短于初始反应。此外，在应激前出现了预期性的条件性皮质酮升高。每天三次随机施加应激刺激，持续5周，导致应激后肾上腺皮质反应呈单峰模式，没有任何预期成分。在每天规律施加应激5周后省略足部电击，仅出现血浆皮质酮的预期性峰值。将日常光照时间从通常的上午6点改为上午4点，导致预期性条件性内分泌反应提前2小时出现。文中讨论了丘脑在适应慢性应激过程中的作用。
