Ramade F, Bayle J D
Physiol Behav. 1984 Jul;33(1):73-80. doi: 10.1016/0031-9384(84)90016-7.
Hemispherectomized pigeons were exposed daily to electrical footshocks delivered for 15 sec, at the same hour, for 8 weeks. Serial blood samples were obtained through a chronic vascular catheter. The adrenocortical response to chronic intermittent stress was measured kinetically at one week intervals. The initial response including several successive peaks of plasma corticosterone progressively adapted: Late peaks disappeared and only the first one subsisted 12-14 min after stressor application; this first peak diminished in magnitude; furthermore, an anticipatory peak occurred, starting 14 min before stress. In pigeons lesioned in the anterior dorsomedial thalamus, the only response to the stressor was of the single peak (12-14 min) type without any development of anticipatory conditioned response. This phenomenon was consistant all over the experimental period. Thalamic-hypothalamic interrelationships may be suggested to provide neuronal loops that underlie the long lasting, pulsatile repetitive components of the adrenocortical response to acute stress and also the adaptative process of such a response to chronic intermittent stress, including a conditioned, anticipatory endocrine activation.
对接受了大脑半球切除术的鸽子，每天在同一时间施加15秒的足部电击，持续8周。通过慢性血管导管采集系列血样。每隔一周动态测量肾上腺皮质对慢性间歇性应激的反应。最初的反应包括血浆皮质酮的几个连续峰值，逐渐出现适应性变化：后期的峰值消失，应激源施加后12 - 14分钟仅留存第一个峰值；这个第一个峰值的幅度减小；此外，在应激前14分钟开始出现一个预期峰值。在丘脑前背内侧受损的鸽子中，对应激源的唯一反应是单峰（12 - 14分钟）类型，没有任何预期条件反应的发展。在整个实验期间，这种现象是一致的。丘脑 - 下丘脑的相互关系可能提示存在神经元回路，这些回路是肾上腺皮质对急性应激的持久、搏动性重复成分以及这种反应对慢性间歇性应激的适应性过程（包括条件性、预期性内分泌激活）的基础。
