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英国父母对强制性疫苗接种计划的偏好:一项离散选择实验。

Parental preferences for a mandatory vaccination scheme in England: A discrete choice experiment.

作者信息

Smith Louise E, Carter Ben

机构信息

Department of Psychological Medicine, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Weston Education Centre, Cutcombe Road, London SE5 9RJ, UK.

NIHR Health Protection Research Unit in Emergency Preparedness and Response, UK.

出版信息

Lancet Reg Health Eur. 2022 Apr 13;16:100359. doi: 10.1016/j.lanepe.2022.100359. eCollection 2022 May.

Abstract

BACKGROUND

Mandatory vaccination has been mooted to combat falling childhood vaccine uptake rates in England. This study investigated parental preferences for a mandatory vaccination scheme.

METHODS

Discrete choice experiment. Six attributes were investigated: vaccine, child age group, incentive, penalty, ability to opt out, and compensation scheme. Mixed effects conditional logit regression models were used to investigate parental preferences and relative importance of attributes.

FINDINGS

Participants were 1,001 parents of children aged 5 years and under in England (53% female; mean age=33·6 years, SD=7·1; 84% white). Parental preferences were mostly based on incentives (30·7% relative importance; 80·9% [95% confidence interval 76·3-85·0%] preference for parent and 74·8% [71·0-78·3%] for child incentive; reference: no incentive) and penalties (25·4% relative importance; 69·5% [65·7-73·1%] preference for schemes where unvaccinated children cannot attend school or day care and 67·6% [63·6-71·4%] for those withholding financial benefits for parents of unvaccinated children; reference: £450 fine). Parents also preferred schemes that: offered a compensation scheme (18·1% relative importance; 66·4% [62·7-69·8%] preference; reference: not offered), mandated vaccination in children aged 2 years (versus 5 years; 11·4% relative importance; 42·6% [39·4-45·9%] preference; reference: 2 years), mandated the 6-in-1 vaccine (10·5% relative importance; 58·2% [54·6-61·7%] preference; reference: MMR), and that offered only medical exemptions (versus medical and religious belief exemptions; 4·0% relative importance; 45·5% [41·1-50·0%] preference; reference: medical exemptions).

INTERPRETATION

These findings can inform policymakers' decisions about how best to implement a mandatory childhood vaccination scheme in England.

FUNDING

Data collection was funded by a British Academy/Leverhulme Small Research Grants (SRG1920\101118).

摘要

背景

为应对英国儿童疫苗接种率下降的情况,有人提出了强制接种疫苗的建议。本研究调查了父母对强制接种疫苗计划的偏好。

方法

离散选择实验。研究了六个属性:疫苗、儿童年龄组、激励措施、惩罚措施、选择退出的能力和补偿计划。使用混合效应条件逻辑回归模型来研究父母的偏好和属性的相对重要性。

结果

参与者为1001名英格兰5岁及以下儿童的父母(女性占53%;平均年龄=33.6岁,标准差=7.1;84%为白人)。父母的偏好主要基于激励措施(相对重要性为30.7%;80.9%[95%置信区间76.3 - 85.0%]的人偏好给父母的激励措施,74.8%[71.0 - 78.3%]的人偏好给儿童的激励措施;参考:无激励措施)和惩罚措施(相对重要性为25.4%;69.5%[65.7 - 73.1%]的人偏好未接种疫苗的儿童不能上学或日托的计划,67.6%[63.6 - 71.4%]的人偏好不给未接种疫苗儿童的父母提供经济福利的计划;参考:450英镑罚款)。父母还更喜欢以下计划:提供补偿计划(相对重要性为18.1%;66.4%[62.7 - 69.8%]的人偏好;参考:未提供)、对2岁儿童强制接种疫苗(而非5岁;相对重要性为11.4%;42.6%[39.4 - 45.9%]的人偏好;参考:2岁)、强制接种6合1疫苗(相对重要性为10.5%;58.2%[54.6 - 61.7%]的人偏好;参考:麻疹、腮腺炎和风疹联合疫苗),以及只提供医疗豁免(而非医疗和宗教信仰豁免;相对重要性为4.0%;45.5%[41.1 - 50.0%]的人偏好;参考:医疗豁免)。

解读

这些发现可为政策制定者决定如何在英国最好地实施强制儿童疫苗接种计划提供参考。

资金

数据收集由英国学术院/利华休姆小型研究基金(SRG1920\101118)资助。

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