Akefe Isaac Oluwatobi, Adegoke Victoria Aderonke, Lamidi Ibrahim Yusuf, Ameh Matthew Phillip, Idoga Enokela Shaibu, Ubah Simon Azubuike, Ajayi Itopa Etudaye
Department of Physiology, Biochemistry, and Pharmacology, Faculty of Veterinary Medicine, University of Jos, Jos, Nigeria.
The University of Queensland, School of Biomedical Sciences, Brisbane, Queensland, Australia.
Curr Res Pharmacol Drug Discov. 2022 May 4;3:100106. doi: 10.1016/j.crphar.2022.100106. eCollection 2022.
The occurrence of chronic neurodegenerative disorders is on the rise, but with no effective treatment due to the paucity of information on the pathological mechanism underlying these disorders. Thus, this study investigated the role of oral administration of myrtenal in mitigating memory deficits and neuro-biochemical alterations in streptozotocin-demented mice model. Mice (n = 35) were randomly allocated into five cohorts consisting of 7 mice each; Group I: Control mice received vehicle alone; Group II: streptozotocin; Group III: streptozotocin + 100 mg/kg myrtenal; Group IV: streptozotocin +200 mg/kg myrtenal; and Group V: streptozotocin + donepezil 0.5 mg/kg. Data from this study demonstrated that the administration of streptozotocin (STZ) impaired spatial memory and induced alterations in markers of oxido-inflammatory response, cholinergic function, cytoarchitecture, and neurotransmitter levels in mice hippocampus. Notably, administration of myrtenal enhanced spatial memory performance in STZ-demented mice by improving the activities of endogenous antioxidant enzymes to protect the brain from oxido-inflammatory stress. Treatment with myrtenal also restored cholinergic function and stabilized the homeostasis of neurotransmitters in STZ-demented mice. The authors infer that fruits rich in myrtenal may be beneficial for treating patients living with dementia associated with Alzheimer's disease.
慢性神经退行性疾病的发病率正在上升，但由于对这些疾病潜在病理机制的信息匮乏，目前尚无有效的治疗方法。因此，本研究调查了口服桃金娘烯醛对减轻链脲佐菌素致痴呆小鼠模型记忆缺陷和神经生化改变的作用。将35只小鼠随机分为5组，每组7只；第一组：对照小鼠仅接受赋形剂；第二组：链脲佐菌素；第三组：链脲佐菌素 + 100毫克/千克桃金娘烯醛；第四组：链脲佐菌素 + 200毫克/千克桃金娘烯醛；第五组：链脲佐菌素 + 0.5毫克/千克多奈哌齐。本研究数据表明，链脲佐菌素（STZ）给药损害了小鼠的空间记忆，并诱导了氧化炎症反应、胆碱能功能、细胞结构和小鼠海马体神经递质水平标志物的改变。值得注意的是，桃金娘烯醛给药通过提高内源性抗氧化酶的活性来保护大脑免受氧化炎症应激，从而增强了STZ致痴呆小鼠的空间记忆表现。桃金娘烯醛治疗还恢复了STZ致痴呆小鼠的胆碱能功能，并稳定了神经递质的稳态。作者推断，富含桃金娘烯醛的水果可能对治疗患有阿尔茨海默病相关痴呆症的患者有益。
