Hamory B H, Sande M A, Sydnor A, Seale D L, Gwaltney J M
J Infect Dis. 1979 Feb;139(2):197-202. doi: 10.1093/infdis/139.2.197.
Eighty-one adults with symptoms of acute sinusitis were studied by direct needle puncture and aspiration of the maxillary sinus (105 sinuses). Fifty-nine bacterial strains were isolated in titers of greater than or equal to 10(4) colony-forming units/ml; Streptococcus pneumoniae and Haemophilus influenzae accounted for 64% of the isolates. Other bacteria recovered included anaerobes (12%), Neisseria species (8.5%). Streptococcus pyogenes (3%), alpha-hemolytic Streptococcus (3%), non-group A beta-hemolytic Streptococcus (3%), Staphylococcus aureus (2%), Pseudomonas aeruginosa (2%), and Escherichia coli (2%). Viruses were isolated from 11 sinuses; these isolates included rhinovirus (six), influenza A (H3N2) virus (three), and two types of parainfluenza virus (one each). The efficacy of therapy with orally administered ampicillin, amoxicillin, or trimethoprim-sulfamethoxazole was evaluated by a repeat sinus puncture and culture. Clinical and bacteriologic responses to all three regimens were good.
对81名有急性鼻窦炎症状的成年人进行了研究，通过对上颌窦进行直接针刺抽吸（共105个鼻窦）。分离出59株细菌，滴度大于或等于10⁴菌落形成单位/毫升；肺炎链球菌和流感嗜血杆菌占分离株的64%。分离出的其他细菌包括厌氧菌（12%）、奈瑟菌属（8.5%）、化脓性链球菌（3%）、α溶血性链球菌（3%）、非A组β溶血性链球菌（3%）、金黄色葡萄球菌（2%）、铜绿假单胞菌（2%）和大肠杆菌（2%）。从11个鼻窦中分离出病毒；这些分离株包括鼻病毒（6株）、甲型流感（H3N2）病毒（3株）和两种副流感病毒（各1株）。通过重复鼻窦穿刺和培养评估口服氨苄西林、阿莫西林或甲氧苄啶-磺胺甲恶唑治疗的疗效。对所有三种治疗方案的临床和细菌学反应均良好。
