Shapiro E D, Milmoe G J, Wald E R, Rodnan J B, Bowen A D
J Infect Dis. 1982 Nov;146(5):589-93. doi: 10.1093/infdis/146.5.589.
The maxillary sinuses of 20 patients (median age, 15 years) with cystic fibrosis were examined with ultrasound, radiography, and transantral sinus aspiration (14 bilateral and six unilateral for a total of 34 aspirates). The sinus aspirations were performed with careful sterile techniques, and the material that was recovered was cultured quantitatively for both aerobic and anaerobic bacteria. Nineteen (95%) of the 20 patients had at least one positive (greater than or equal to 10(4) colony-forming units/ml) culture of sinus aspirate. The organisms most commonly recovered from the sinus aspirates were Pseudomonas aeruginosa (13), Haemophilus influenzae (10), streptococci (five), and anaerobes (five). There was no association between the bacterial species recovered from the sinus and the predominant bacterial species in the nasopharyngeal, throat, or sputum culture. Although most patients had been chronically receiving therapeutic oral doses of antimicrobial agents, bacteria sensitive to the antimicrobial agents that the patient had been taking (excluding P. aeruginosa) were recovered from the sinuses of nine of these 10 patients.
对20例囊性纤维化患者（中位年龄15岁）的上颌窦进行了超声、放射照相及经窦抽吸检查（14例双侧，6例单侧，共34次抽吸）。窦抽吸操作采用严格的无菌技术，对获取的材料进行需氧菌和厌氧菌的定量培养。20例患者中有19例（95%）窦抽吸培养至少有一次阳性（≥10⁴菌落形成单位/毫升）。从窦抽吸物中最常分离出的微生物为铜绿假单胞菌（13例）、流感嗜血杆菌（10例）、链球菌（5例）和厌氧菌（5例）。从窦中分离出的细菌种类与鼻咽、咽喉或痰液培养中的主要细菌种类之间无关联。尽管大多数患者长期接受治疗剂量的口服抗菌药物，但在这10例患者中有9例的窦中分离出了对患者所服用抗菌药物敏感的细菌（不包括铜绿假单胞菌）。
