Peltola Ville T, Boyd Kelli L, McAuley Julie L, Rehg Jerold E, McCullers Jonathan A
Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105-2794, USA.
Infect Immun. 2006 May;74(5):2562-7. doi: 10.1128/IAI.74.5.2562-2567.2006.
Streptococcus pneumoniae is the leading cause of otitis media, sinusitis, and pneumonia. Many of these infections result from antecedent influenza virus infections. In this study we sought to determine whether the frequency and character of secondary pneumococcal infections differed depending on the strain of influenza virus that preceded bacterial challenge. In young ferrets infected with influenza virus and then challenged with pneumococcus, influenza viruses of any subtype increased bacterial colonization of the nasopharynx. Nine out of 10 ferrets infected with H3N2 subtype influenza A viruses developed either sinusitis or otitis media, while only 1 out of 11 ferrets infected with either an H1N1 influenza A virus or an influenza B virus did so. These data may partially explain why bacterial complication rates are higher during seasons when H3N2 viruses predominate. This animal model will be useful for further study of the mechanisms that underlie viral-bacterial synergism.
肺炎链球菌是中耳炎、鼻窦炎和肺炎的主要病因。这些感染中的许多是由先前的流感病毒感染引起的。在本研究中，我们试图确定继发性肺炎球菌感染的频率和特征是否因细菌攻击之前的流感病毒株而异。在感染流感病毒后再受到肺炎球菌攻击的幼雪貂中，任何亚型的流感病毒都会增加鼻咽部的细菌定植。感染H3N2亚型甲型流感病毒的10只雪貂中有9只发生了鼻窦炎或中耳炎，而感染甲型H1N1流感病毒或乙型流感病毒的11只雪貂中只有1只发生了这种情况。这些数据可能部分解释了为什么在H3N2病毒占主导的季节中细菌并发症发生率更高。这种动物模型将有助于进一步研究病毒 - 细菌协同作用的潜在机制。
