GENYO, Centre for Genomics and Oncological Research, Pfizer, University of Granada, Granada, Spain.
Microbiology Unit, University Hospital Virgen de las Nieves, Biosanitary Research Institute (IBS.Granada), Granada, Spain.
Front Cell Infect Microbiol. 2021 May 18;11:617002. doi: 10.3389/fcimb.2021.617002. eCollection 2021.
The application of next generation sequencing techniques has allowed the characterization of the urinary tract microbiome and has led to the rejection of the pre-established concept of sterility in the urinary bladder. Not only have microbial communities in the urinary tract been implicated in the maintenance of health but alterations in their composition have also been associated with different urinary pathologies, such as urinary tract infections (UTI). Therefore, the study of the urinary microbiome in healthy individuals, as well as its involvement in disease through the proliferation of opportunistic pathogens, could open a potential field of study, leading to new insights into prevention, diagnosis and treatment strategies for urinary pathologies. In this review we present an overview of the current state of knowledge about the urinary microbiome in health and disease, as well as its involvement in the development of new therapeutic strategies.
下一代测序技术的应用使得尿路微生物组的特征得以描述，并导致人们摒弃了膀胱无菌的既定概念。不仅尿路微生物群落与健康的维持有关，其组成的改变也与不同的尿路病理有关，如尿路感染（UTI）。因此，研究健康个体的尿路微生物组及其通过机会性病原体的增殖在疾病中的作用，可能开辟一个潜在的研究领域，为尿路疾病的预防、诊断和治疗策略提供新的见解。在这篇综述中，我们概述了目前关于健康和疾病中尿路微生物组的知识状况，以及其在新治疗策略发展中的作用。
