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[肌皮瓣和庆大霉素聚甲基丙烯酸甲酯珠对褥疮的一期即时覆盖]

[Primary immediate coverage of decubitus ulcers by musculocutaneous flaps and gentamicin PMMA beads].

作者信息

Priesack W, Fuchs K H, Bauer E

出版信息

Handchir Mikrochir Plast Chir. 1987 Jan;19(1):10-6.

PMID:3557201
Abstract

Myo- or fasciocutaneous flaps for coverage of longstanding pressure sores in para- or quadriplegic patients have been proved superior to cutaneous flaps. Pretreatment with ulcer-debridement and systemic antibiotics for urinary-tract-infection and septicaemia was thought to be necessary for successful closure of these difficult defects. In a prospective, clinical trial 17 patients with 20 pressure sores were treated this way during 1980-1983. From 1983-1985 no local or antibiotic treatment was given to a second group of 20 patients with 28 decubitus ulcers prior to a one-stage-closure of the pressure sores. Only five patients with septicaemia above 39 degrees C received antibiotics intraoperatively. Gentamicin-PMMA-beads were temporarily inserted under the myo- or fasciocutaneous flaps during the procedure. If necessary, urinary-tract-infection was treated after successful coverage. Both groups have been compared historically. There were less wound complications in the second group while a median time-saving of 2 1/2 weeks per patient could be gained, even though they had larger pressure sores, frequent bone involvement, and multiple ulcers in this group.

摘要

肌皮瓣或筋膜皮瓣用于覆盖截瘫或四肢瘫患者的长期压疮,已被证明优于皮瓣。对于这些难以闭合的创面,术前进行溃疡清创以及针对尿路感染和败血症使用全身抗生素治疗被认为是成功闭合创面的必要措施。在一项前瞻性临床试验中,1980年至1983年期间,17例患有20处压疮的患者接受了这种治疗方式。1983年至1985年期间,在对20例患有28处褥疮的患者进行一期闭合压疮之前,未对其进行局部治疗或抗生素治疗。只有5例体温高于39摄氏度的败血症患者在术中接受了抗生素治疗。在手术过程中,将庆大霉素-聚甲基丙烯酸甲酯珠临时置于肌皮瓣或筋膜皮瓣下方。如有必要,在成功覆盖创面后治疗尿路感染。对两组进行了历史对照比较。第二组的伤口并发症较少,尽管该组患者的压疮面积更大、频繁累及骨骼且有多处溃疡,但每位患者平均可节省2.5周的时间。

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