Cohn R A, Mauer S M, Barbosa J, Michael A F
Lab Invest. 1978 Jul;39(1):13-6.
Skeletal muscle from 34 insulin-dependent diabetic patients and 20 age-matched controls was examined by immunofluorescent microscopy. Significantly increased staining of capillary and muscle basement membranes of diabetics was seen for IgG, albumin, and fibrin. The immunofluorescent pattern was identical with that observed using heterologous antibasement membrane antiserum, indicating that these proteins were present within these basement membranes. No differences were detected between males and females or between kidney-transplanted and nontransplanted diabetics. No correlation was noted between intensity of staining and duration of diabetes. The presence of certain serum proteins within vascular and nonvascular basement membranes in diabetics is not restricted to the kidney and may reflect widespread alterations in extracellular membranes that permit entrapment of these proteins.
通过免疫荧光显微镜检查了34名胰岛素依赖型糖尿病患者和20名年龄匹配的对照者的骨骼肌。糖尿病患者的毛细血管和肌肉基底膜上IgG、白蛋白和纤维蛋白的染色显著增加。免疫荧光模式与使用异源抗基底膜抗血清观察到的模式相同，表明这些蛋白质存在于这些基底膜内。男性和女性之间、肾移植糖尿病患者和未移植糖尿病患者之间未检测到差异。染色强度与糖尿病病程之间未发现相关性。糖尿病患者血管和非血管基底膜中某些血清蛋白的存在并不局限于肾脏，可能反映了细胞外膜的广泛改变，从而允许这些蛋白质滞留。
