Zierhut Marco, Böge Kerem, Bergmann Niklas, Hahne Inge, Braun Alice, Kraft Julia, Ta Thi Minh Tam, Ripke Stephan, Bajbouj Malek, Hahn Eric
Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
BIH Charitè Junior Clinician Scientist Program, BIH Biomedical Innovation Academy, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Front Psychiatry. 2022 Apr 27;13:865226. doi: 10.3389/fpsyt.2022.865226. eCollection 2022.
Current research suggests that emotion recognition is impaired in individuals affected by schizophrenia spectrum disorders (SSD). However, the specific impact of negative symptoms on the ability to recognize single basic emotions has not yet been explored sufficiently and is the aim of the present study. A sample of = 66 individuals diagnosed with SSD was recruited at the Charité - Universitätsmedizin Berlin. In a first step, correlation analyses were conducted between seven different negative symptom subdomains of the Positive and Negative Syndrome Scale (PANSS) and the accuracy and latency in recognizing the six basic emotions (anger, disgust, fear, happiness, sadness, surprise) using the Emotion Recognition Task (ERT) of the Cambridge Neuropsychological Test Automated Battery (CANTAB). The significant correlations were subjected to linear regression models that controlled for the significant covariates diagnoses, age, sex, and education. Results revealed that in individuals with SSD the negative symptom domain of blunted affect significantly predicted the accuracy of emotion recognition performance ( < 0.05), particularly, when recognizing happiness ( < 0.05). Additionally, we found that stereotyped thinking also predicted the performance of emotion recognition, especially the response latency ( < 0.05) and difficulty in abstract thinking predicted the recognition of fear ( < 0.05). However, the nominal significances did not withstand correction for multiple tests and therefore need to be followed up in further studies with a larger sample.
当前研究表明，精神分裂症谱系障碍（SSD）患者的情绪识别能力受损。然而，阴性症状对识别单一基本情绪能力的具体影响尚未得到充分探究，而这正是本研究的目的。在柏林夏里特大学医学中心招募了66名被诊断为SSD的个体作为样本。第一步，使用剑桥神经心理测试自动成套系统（CANTAB）的情绪识别任务（ERT），对阳性和阴性症状量表（PANSS）的七个不同阴性症状子领域与识别六种基本情绪（愤怒、厌恶、恐惧、快乐、悲伤、惊讶）的准确性和潜伏期进行相关性分析。将显著相关性纳入线性回归模型，该模型控制了显著的协变量诊断、年龄、性别和教育程度。结果显示，在患有SSD的个体中，情感迟钝的阴性症状领域显著预测了情绪识别表现的准确性（<0.05），特别是在识别快乐情绪时（<0.05）。此外，我们发现刻板思维也预测了情绪识别表现，尤其是反应潜伏期（<0.05），而抽象思维困难预测了对恐惧情绪的识别（<0.05）。然而，这些名义上的显著性在多重检验校正后并不成立，因此需要在更大样本的进一步研究中进行跟进。
