Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Physiology (Bethesda). 2022 Sep 1;37(5):0. doi: 10.1152/physiol.00002.2022. Epub 2022 May 16.
Laboratory rodents and cold-adapted animals in the wild use a significant amount of the energy derived from food intake for heat generation. Thermogenesis involving mitochondrial uncoupling in the brown adipose tissue differs quantitatively in mice, humans, and cold-adapted animals and could be an important ally to combat obesity if humans were prepared to deviate slightly from thermoneutral living conditions to activate this pathway.
实验啮齿动物和野外适应寒冷的动物会从食物摄入中获取大量能量用于产热。涉及棕色脂肪组织中线粒体解偶联的产热在小鼠、人类和适应寒冷的动物中存在定量差异，如果人类准备稍微偏离热中性生活条件来激活这条途径，那么这种产热可能成为对抗肥胖的重要盟友。
