Cao Dengjie, Xie Yujie, Song Jie
Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
School of Medicine, Shanghai University, Shanghai, 200444, China.
Macromol Rapid Commun. 2022 Oct;43(19):e2200281. doi: 10.1002/marc.202200281. Epub 2022 May 26.
Tailoring the mechanical properties has always been a key to the field of hydrogels in terms of different applications. Particularly, DNA hydrogels offer an unambiguous way to precisely tune the mechanical properties, largely on account of their programmable sequences, abundant responding toolbox, and various ligation approaches. In this review, DNA hydrogels from the perspective of mechanical properties, from a synthetic standpoint to different applications, are introduced. The relationship between the structure and their mechanical properties in DNA hydrogels and the methods of regulating the mechanical properties of DNA hydrogels are specifically summarized. Furthermore, several recent applications of DNA hydrogels in relation to their mechanical properties are discussed. Benefiting from the tunability and flexibility, rational design of mechanical properties in DNA hydrogels provided unheralded interest from fundamental science to extensive applications.
根据不同的应用来定制机械性能一直是水凝胶领域的关键。特别是，DNA水凝胶提供了一种明确的方法来精确调节机械性能，这主要归功于其可编程的序列、丰富的响应工具箱以及各种连接方法。在这篇综述中，从机械性能的角度，从合成的观点到不同的应用，介绍了DNA水凝胶。特别总结了DNA水凝胶中结构与其机械性能之间的关系以及调节DNA水凝胶机械性能的方法。此外，还讨论了DNA水凝胶在其机械性能方面的一些最新应用。得益于其可调性和灵活性，DNA水凝胶中机械性能的合理设计从基础科学到广泛应用都引起了前所未有的关注。
